Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage (Q45050515)

8 December 2017

title

Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage (English)

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8 December 2017

Tianyun Jiang

1

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8 December 2017

Zhiyong Guo

2

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8 December 2017

Bojie Dai

3

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8 December 2017

Miyoung Kang

4

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8 December 2017

David K Ann

5

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8 December 2017

Hsing-Jien Kung

6

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8 December 2017

Yun Qiu

7

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8 December 2017

language of work or name

English

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publication date

8 September 2004

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Journal of Biological Chemistry

8 December 2017

published in

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8 December 2017

volume

279

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8 December 2017

issue

48

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8 December 2017

page(s)

50181-50189

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DNA damage-induced apoptosis

8 December 2017

cites work

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PUMA, a novel proapoptotic gene, is induced by p53

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Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

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Negative regulation of bcl-2 expression by p53 in hematopoietic cells

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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p53 has a direct apoptogenic role at the mitochondria

21 January 2018

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

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The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells

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Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

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Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

21 January 2018

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Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

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Retroviral delivery of small interfering RNA into primary cells

21 January 2018

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Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

21 January 2018

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Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

21 January 2018

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Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking

21 January 2018

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Functional inactivation but not structural mutation of p53 causes liver cancer.

21 January 2018

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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

21 January 2018

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Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M409108200

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8 December 2017

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