PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation (Q44737480)

5 December 2017

title

PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation (English)

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5 December 2017

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lymphoblastic leukemia

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2

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5 December 2017

Jiffar T

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5 December 2017

Suck G

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5 December 2017

Carlson-Bremer D

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5 December 2017

Ricciardi MR

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5 December 2017

Konopleva M

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Andreeff M

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5 December 2017

Ruvolo PP

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5 December 2017

publication date

1 March 2004

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5 December 2017

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5 December 2017

volume

18

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5 December 2017

issue

3

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5 December 2017

page(s)

505-512

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Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

5 December 2017

cites work

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https://api.crossref.org/works/10.1038/SJ.LEU.2403275

Protein kinase C: structure, function, and regulation

21 January 2018

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Multiple pathways control protein kinase C phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403275

Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex

21 January 2018

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A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

21 January 2018

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Bcl-2 phosphorylation required for anti-apoptosis function

21 January 2018

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Raf-1 activates MAP kinase-kinase

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Serine/threonine phosphorylation in cytokine signal transduction

21 January 2018

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Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells

21 January 2018

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Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium

21 January 2018

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Functions of ceramide in coordinating cellular responses to stress

21 January 2018

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Ceramide in the eukaryotic stress response

21 January 2018

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Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?

21 January 2018

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A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function

21 January 2018

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Ceramide regulates cellular homeostasis via diverse stress signaling pathways

21 January 2018

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Intracellular signal transduction pathways activated by ceramide and its metabolites

21 January 2018

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Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

21 January 2018

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Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

21 January 2018

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Biochemical pathways of caspase activation during apoptosis

21 January 2018

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

21 January 2018

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Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

21 January 2018

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Ceramide inactivates cellular protein kinase Calpha

21 January 2018

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Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.

21 January 2018

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Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

21 January 2018

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The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

21 January 2018

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Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies

21 January 2018

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Altered expression of cyclins and c-fos in R6 cells that overproduce PKC epsilon

21 January 2018

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Inactivation of Bcl-2 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403275

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2403275

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

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Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A

21 January 2018

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Protein kinase C isozymes and the regulation of diverse cell responses

21 January 2018

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7 January 2021

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

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https://api.crossref.org/works/10.1038/SJ.LEU.2403275

7 January 2021

Loss of protein kinase C function induces an apoptotic response

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https://api.crossref.org/works/10.1038/SJ.LEU.2403275

7 January 2021

Protein kinase Czeta is a negative regulator of protein kinase B activity

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https://api.crossref.org/works/10.1038/SJ.LEU.2403275

7 January 2021

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

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7 January 2021

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403275

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5 December 2017

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