Proteasomal inhibition by alpha-synuclein filaments and oligomers. (Q44719233)

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17 November 2019

title

Proteasomal inhibition by alpha-synuclein filaments and oligomers (English)

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17 November 2019

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4

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17 November 2019

Poul Henning Jensen

7

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17 November 2019

author name string

Evo Lindersson

1

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17 November 2019

Rasmus Beedholm

2

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17 November 2019

Peter Højrup

3

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17 November 2019

WeiPing Gai

5

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17 November 2019

Klavs B Hendil

6

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17 November 2019

language of work or name

English

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publication date

7 January 2004

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Journal of Biological Chemistry

17 November 2019

published in

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17 November 2019

volume

279

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17 November 2019

issue

13

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17 November 2019

page(s)

12924-12934

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

17 November 2019

cites work

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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

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Widespread alterations of alpha-synuclein in multiple system atrophy

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Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model

21 January 2018

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

21 January 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

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A Drosophila model of Parkinson's disease

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

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Failure of the ubiquitin-proteasome system in Parkinson's disease

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Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease

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Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

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Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

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Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

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Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC

21 January 2018

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Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments

21 January 2018

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26 S proteasomes function as stable entities

21 January 2018

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Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

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Mild stress-induced stimulation of heat-shock protein synthesis and improved functional ability of human fibroblasts undergoing aging in vitro

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α-Synuclein in Lewy bodies

21 January 2018

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A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

21 January 2018

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alpha-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy.

21 January 2018

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

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Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

21 January 2018

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

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21 January 2018

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Proteasome inhibitors: from research tools to drug candidates

21 January 2018

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Purification and characterization of an endogenous inhibitor specific to the Z-Leu-Leu-Leu-MCA degrading activity in proteasome and its identification as heat-shock protein 90.

21 January 2018

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Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis

21 January 2018

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

21 January 2018

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beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

21 January 2018

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M306390200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14711827 AND SRC:MED&resulttype=core&format=json

17 November 2019

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