Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. (Q44655988)

5 December 2017

title

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. (English)

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5 December 2017

5

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5 December 2017

Ayaz Najafov

1

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Eeva M Sommer

series ordinal

2

object named as

Eeva M Sommer

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5 December 2017

Jeffrey M Axten

3

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5 December 2017

M Phillip Deyoung

series ordinal

4

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5 December 2017

language of work or name

English

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publication date

1 January 2011

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5 December 2017

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5 December 2017

volume

433

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5 December 2017

issue

2

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5 December 2017

page(s)

357-369

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PDK1, the master regulator of AGC kinase signal transduction

5 December 2017

cites work

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The nuts and bolts of AGC protein kinases

21 January 2018

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AKT/PKB signaling: navigating downstream

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Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

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Serum and glucocorticoid-regulated protein kinases: variations on a theme

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The RSK family of kinases: emerging roles in cellular signalling

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The life and death of protein kinase C.

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3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma

21 January 2018

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Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN( /-) mice

21 January 2018

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Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

21 January 2018

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New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

21 January 2018

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Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

21 January 2018

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Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

21 January 2018

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Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

21 January 2018

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Discovery of dibenzo[c,f][2,7]naphthyridines as potent and selective 3-phosphoinositide-dependent kinase-1 inhibitors

21 January 2018

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From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors

21 January 2018

1 reference

Small-molecule inhibitors of PDK1.

21 January 2018

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TOR signaling in growth and metabolism

21 January 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

21 January 2018

1 reference

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

21 January 2018

1 reference

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

21 January 2018

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

21 January 2018

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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

21 January 2018

1 reference

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

21 January 2018

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High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

21 January 2018

1 reference

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

21 January 2018

1 reference

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

21 January 2018

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In vivo role of the phosphate groove of PDK1 defined by knockin mutation

21 January 2018

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High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

21 January 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

21 January 2018

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The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

21 January 2018

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

21 January 2018

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Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

21 January 2018

1 reference

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

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Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

21 January 2018

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Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

21 January 2018

1 reference

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 January 2018

1 reference

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

21 January 2018

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Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation

21 January 2018

1 reference

Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells

21 January 2018

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

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Essential role of PDK1 in regulating cell size and development in mice

21 January 2018

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The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

21 January 2018

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 January 2018

1 reference

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 January 2018

1 reference

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

21 January 2018

1 reference

Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

21 January 2018

1 reference

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 January 2018

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RSK and MSK in MAP kinase signalling

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20101732

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5 December 2017

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