BACE-2 is overexpressed in Down's syndrome. (Q44535324)

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6 November 2019

title

BACE-2 is overexpressed in Down's syndrome (English)

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6 November 2019

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2

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6 November 2019

Roberta Ghidoni

3

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6 November 2019

Claudio Russo

5

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6 November 2019

Giuliano Binetti

13

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6 November 2019

author name string

L Barbiero

1

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6 November 2019

A Alberici

4

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6 November 2019

G Schettini

6

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6 November 2019

S F Pagano

7

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6 November 2019

E A Parati

8

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6 November 2019

F Mazzoli

9

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6 November 2019

F Nicosia

10

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6 November 2019

S Signorini

11

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6 November 2019

E Feudatari

12

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6 November 2019

language of work or name

English

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publication date

1 August 2003

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6 November 2019

published in

Experimental Neurology

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6 November 2019

volume

182

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6 November 2019

issue

2

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6 November 2019

page(s)

335-345

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The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

6 November 2019

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Do rodent and human brains have different N-glycosylation patterns?

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Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

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Expression analysis of BACE2 in brain and peripheral tissues

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Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome.

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Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease

7 January 2021

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

7 January 2021

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A non-amyloidogenic function of BACE-2 in the secretory pathway

7 January 2021

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Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain.

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Down syndrome phenotypes: the consequences of chromosomal imbalance

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Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis

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Cerebral amyloidosis, ageing and Alzheimer's disease; a contribution from studies on Down's syndrome.

7 January 2021

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The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

7 January 2021

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The topography of plaques and tangles in Down's syndrome patients of different ages

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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The ups and downs of Down's syndrome

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Alzheimer's disease and down syndrome: from meiosis to dementia

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Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

7 January 2021

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A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

7 January 2021

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

7 January 2021

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The Dementia of Down's Syndrome and its Relevance to Aetiological Studies of Alzheimer's Disease

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7 January 2021

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7 January 2021

Identifiers

DOI

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6 November 2019

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