Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine. (Q44457504)

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8 April 2020

title

Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine (English)

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7

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Volker M. Arlt

9

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Václav Martínek

10

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Radek Indra

2

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Zbyněk Heger

8

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1

Marie Stiborová

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3

Eva Frei

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5

Heinz H Schmeiser

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author name string

Kateřina Kopečková

4

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Tomáš Eckschlager

6

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publication date

4 July 2017

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8 April 2020

published in

Monatshefte für Chemie

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volume

148

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issue

11

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page(s)

1983-1991

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Creative Commons Attribution 4.0 International

8 April 2020

copyright license

start time

4 July 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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15 August 2018

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Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans.

15 August 2018

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15 August 2018

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The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts

15 August 2018

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alpha-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6.

15 August 2018

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Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase

15 August 2018

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15 August 2018

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The role of oxygenated cytochrome P-450 and of cytochrome b5 in hepatic microsomal drug oxidations

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12 December 2020

Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those foundin vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine

1 reference

12 December 2020

Apo-cytochrome b5 as an indicator of changes in heme accessability: preliminary studies with cytochrome P450 3A4

1 reference

12 December 2020

Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems

1 reference

12 December 2020

Cytochrome b5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy

1 reference

12 December 2020

10.1007/S00706-017-1986-9

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104319 AND SRC:MED&resulttype=core&format=json

8 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29104319 AND SRC:MED&resulttype=core&format=json

8 April 2020

PubMed publication ID

29104319

1 reference