The combination of 4-1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV-specific T cell responses (Q44436557)

3 December 2017

title

The combination of 4-1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV-specific T cell responses (English)

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5

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Brenda De Keersmaecker

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Brenda De Keersmaecker

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author name string

Carlo Heirman

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Jurgen Corthals

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Christophe Empsen

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Sabine D Allard

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Joeri Pen

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Patrick Lacor

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Kris Thielemans

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Joeri L Aerts

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publication date

22 March 2011

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Journal of Leukocyte Biology

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published in

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volume

89

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issue

6

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page(s)

989-999

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8 T cells

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cites work

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Therapeutic dendritic-cell vaccine for chronic HIV-1 infection

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Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor.

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Cutting edge: Expression of functional CD137 receptor by dendritic cells

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The Structure of the Trimer of Human 4-1BB Ligand Is Unique among Members of the Tumor Necrosis Factor Superfamily

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4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12.

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TNF/TNFR family members in costimulation of T cell responses

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Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses

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4-1BB promotes the survival of CD8 T lymphocytes by increasing expression of Bcl-xL and Bfl-1.

21 January 2018

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Activation of human dendritic cells through CD40 cross-linking.

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

21 January 2018

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CD40 ligation releases immature dendritic cells from the control of regulatory CD4 CD25 T cells.

21 January 2018

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Cutting edge: human CD4 CD25 T cells restrain the maturation and antigen-presenting function of dendritic cells

21 January 2018

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Priming of human immunodeficiency virus type 1 (HIV-1)-specific CD8 T cell responses by dendritic cells loaded with HIV-1 proteins

21 January 2018

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Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

21 January 2018

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Functional T-cell responses generated by dendritic cells expressing the early HIV-1 proteins Tat, Rev and Nef.

21 January 2018

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Lumenal part of the DC-LAMP protein is not required for induction of antigen-specific T cell responses by means of antigen-DC-LAMP messenger RNA-electroporated dendritic cells.

21 January 2018

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Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4 CD25 regulatory T cells

21 January 2018

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Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines

21 January 2018

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IL-2 administration increases CD4 CD25(hi) Foxp3 regulatory T cells in cancer patients

21 January 2018

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Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8 T cells responding to antigen without requiring knowledge of epitope specificities

21 January 2018

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Enhancement of HIV-specific CD8 T cell responses by dual costimulation with CD80 and CD137L.

21 January 2018

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Helping the CD8( ) T-cell response

21 January 2018

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Vigorous HIV-1-Specific CD4 T Cell Responses Associated with Control of Viremia

21 January 2018

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4-1BBL costimulation retrieves CD28 expression in activated T cells

21 January 2018

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Differential costimulation through CD137 (4-1BB) restores proliferation of human virus-specific "effector memory" (CD28(-) CD45RA(HI)) CD8( ) T cells

21 January 2018

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Role of T cell costimulation in anti-viral immunity

21 January 2018

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CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

21 January 2018

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Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL.

21 January 2018

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The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells

21 January 2018

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Glucocorticoid-induced tumor necrosis factor receptor family-related protein triggering enhances HIV-specific CD4 T cell cytokine secretion and protects HIV-specific CD4 T cells from apoptosis

21 January 2018

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Multiple roles of TRAF3 signaling in lymphocyte function.

21 January 2018

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Preservation of FoxP3 regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4 T-cell activation.

21 January 2018

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HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.

21 January 2018

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Suppression of HIV-specific T cell activity by lymph node CD25 regulatory T cells from HIV-infected individuals

21 January 2018

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Regulatory T cell suppression of Gag-specific CD8 T cell polyfunctional response after therapeutic vaccination of HIV-1-infected patients on ART.

21 January 2018

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4-1BB-dependent inhibition of immunosuppression by activated CD4 CD25 T cells

21 January 2018

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CD137 costimulation of CD8 T cells confers resistance to suppression by virus-induced regulatory T cells

21 January 2018

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Stimulation of CD25( )CD4( ) regulatory T cells through GITR breaks immunological self-tolerance

21 January 2018

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TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function.

21 January 2018

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Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.

21 January 2018

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Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

21 January 2018

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Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8( ) T cells

21 January 2018

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1189/JLB.0810466

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3 December 2017

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