Upregulation of CTLA-4 by HIV-specific CD4 T cells correlates with disease progression and defines a reversible immune dysfunction (Q44297682)

1 December 2017

title

Upregulation of CTLA-4 by HIV-specific CD4 T cells correlates with disease progression and defines a reversible immune dysfunction (English)

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Bruce D Walker

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Florencia Pereyra

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Alicja Piechocka-Trocha

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object named as

Alicja Piechocka-Trocha

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Eric S Rosenberg

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Gordon J Freeman

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Kristin Moss

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Almas Rathod

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Toshiyuki Miura

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Anthony D Kelleher

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John M Coffin

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John J Zaunders

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Daniel E Kaufmann

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Daniel G Kavanagh

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Elizabeth W Mackey

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Sarah Palmer

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Brett Baker

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Baogong Zhu

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Michael T Waring

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Ryan Ahern

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language of work or name

English

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publication date

30 September 2007

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1 December 2017

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volume

8

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issue

11

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page(s)

1246-1254

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Murine malaria is exacerbated by CTLA-4 blockade

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cites work

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Effects of sustained HIV-1 plasma viremia on HIV-1 Gag-specific CD4 T cell maturation and function

21 January 2018

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Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production

21 January 2018

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21 January 2018

The B7 family revisited

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7 January 2021

Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

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7 January 2021

TNF/TNFR family members in costimulation of T cell responses

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7 January 2021

Restoring function in exhausted CD8 T cells during chronic viral infection

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7 January 2021

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

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7 January 2021

Upregulation of PD-1 expression on HIV-specific CD8 T cells leads to reversible immune dysfunction

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7 January 2021

PD-1 is a regulator of virus-specific CD8 T cell survival in HIV infection

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7 January 2021

Enhancement of antitumor immunity by CTLA-4 blockade

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7 January 2021

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

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7 January 2021

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

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7 January 2021

CTLA-4: new insights into its biological function and use in tumor immunotherapy

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7 January 2021

Mechanisms of suppression by suppressor T cells

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7 January 2021

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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7 January 2021

Induction of CTLA-4-mediated anergy contributes to persistent colonization in the murine model of gastric Helicobacter pylori infection

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7 January 2021

Immunotherapy with OX40L-Fc or anti-CTLA-4 enhances local tissue responses and killing of Leishmania donovani.

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7 January 2021

TGF-beta mediates CTLA-4 suppression of cellular immunity in murine kalaazar

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7 January 2021

CTLA-4 regulates the murine immune response to Trypanosoma cruzi infection.

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7 January 2021

Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.

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7 January 2021

Progress in defining CD4 helper cell responses in chronic viral infections

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7 January 2021

CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques

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7 January 2021

Infection of CD127 (interleukin-7 receptor ) CD4 cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection

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7 January 2021

CTLA-4 upregulation during HIV infection: association with anergy and possible target for therapeutic intervention

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7 January 2021

Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.

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7 January 2021

Fully differentiated HIV-1 specific CD8 T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection

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7 January 2021

A molecular perspective of CTLA-4 function

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7 January 2021

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

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7 January 2021

Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides

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7 January 2021

New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma

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7 January 2021

CD25( )CD4( ) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4( ) and CD8( ) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status

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7 January 2021

HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.

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7 January 2021

Suppression of HIV-specific T cell activity by lymph node CD25 regulatory T cells from HIV-infected individuals

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7 January 2021

Foxp3 programs the development and function of CD4 CD25 regulatory T cells

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7 January 2021

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 T reg cells

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7 January 2021

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

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7 January 2021

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy

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7 January 2021

Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4 T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2

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7 January 2021

Changes in paracrine interleukin-2 requirement, CCR7 expression, frequency, and cytokine secretion of human immunodeficiency virus-specific CD4 T cells are a consequence of antigen load

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7 January 2021

Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25( ) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

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7 January 2021

Analysis of total human immunodeficiency virus (HIV)-specific CD4( ) and CD8( ) T-cell responses: relationship to viral load in untreated HIV infection

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7 January 2021

Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma

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Human immunodeficiency virus type 1 (HIV-1)-specific CD4 T cells that proliferate in vitro detected in samples from most viremic subjects and inversely associated with plasma HIV-1 levels

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Identifiers

DOI

10.1038/NI1515

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1 December 2017

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