Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics (Q44285833)

1 December 2017

title

Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics (English)

1 reference

1 December 2017

1 reference

1 reference

8

Wim Jiskoot

1 reference

1 December 2017

Maryam Ahmadi

1

1 reference

1 December 2017

Christine J Bryson

2

1 reference

1 December 2017

Edward A Cloake

3

1 reference

1 December 2017

Katie Welch

4

1 reference

1 December 2017

Vasco Filipe

5

1 reference

1 December 2017

Stefan Romeijn

6

1 reference

1 December 2017

Andrea Hawe

7

1 reference

1 December 2017

Matthew P Baker

9

1 reference

1 December 2017

Mark H Fogg

10

1 reference

1 December 2017

language of work or name

1 reference

1 April 2015

1 reference

1 December 2017

published in

Pharmaceutical Research

1 reference

1 December 2017

volume

32

1 reference

1 December 2017

issue

4

1 reference

1 December 2017

page(s)

1383-1394

1 reference

Role of repetitive antigen patterns for induction of antibodies against antibodies

1 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Inhibitor development in previously untreated patients with hemophilia A: a prospective long-term follow-up comparing plasma-derived and recombinant products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Protein aggregation: pathways, induction factors and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Stability of protein pharmaceuticals: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Oxidation of therapeutic proteins and peptides: structural and biological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Response of a concentrated monoclonal antibody formulation to high shear

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Detection and characterization of subvisible aggregates of monoclonal IgG in serum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Prediction of immunogenicity of therapeutic proteins: validity of computational tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

IL-2 secretion by CD4 T cells in vivo is rapid, transient, and influenced by TCR-specific competition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

A critical role for IL-21 in regulating immunoglobulin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

IL-21 is an immune activator that also mediates suppression via IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Classification and Characterization of Therapeutic Antibody Aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcgammaRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Prevention of both direct and cross-priming of antitumor CD8 T-cell responses following overproduction of prostaglandin E2 by tumor cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Immunogenicity of subcutaneously administered therapeutic proteins--a mechanistic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Lymphatic transport of proteins after subcutaneous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Preclinical models used for immunogenicity prediction of therapeutic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11095-014-1541-X

Distinct and overlapping roles of interleukin-10 and CD25 regulatory T cells in the inhibition of antitumor CD8 T-cell responses

21 January 2018

1 reference

12 December 2020

Immunogenicity of different brands of human insulin and rapid-acting insulin analogs in insulin-naïve children with type 1 diabetes

1 reference

12 December 2020

Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma

1 reference

12 December 2020

Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells

1 reference

12 December 2020

Chemical stability of insulin. 1. Hydrolytic degradation during storage of pharmaceutical preparations

1 reference

12 December 2020

The influence of antigen organization on B cell responsiveness

1 reference

12 December 2020

Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes

1 reference

12 December 2020

Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress

1 reference

12 December 2020

Longterm safety of patients receiving rituximab in rheumatoid arthritis clinical trials

1 reference

12 December 2020

IL-10 alters DC function via modulation of cell surface molecules resulting in impaired T-cell responses

1 reference

12 December 2020

Glass particles as an adjuvant: A model for adverse immunogenicity of therapeutic proteins

1 reference

12 December 2020

Induction of tolerance by IL-10-treated dendritic cells

1 reference

12 December 2020

Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo

1 reference

12 December 2020

10.1007/S11095-014-1541-X

Identifiers

DOI

1 reference

1 December 2017

1 reference