Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. (Q44226094)

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15 December 2019

title

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6 (English)

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15 December 2019

6

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15 December 2019

Mark John Ingraham Paine

1

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15 December 2019

Mike Sutcliffe

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15 December 2019

author name string

Lesley A McLaughlin

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15 December 2019

Jack U Flanagan

3

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15 December 2019

Carol A Kemp

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C Roland Wolf

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15 December 2019

language of work or name

English

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publication date

22 November 2002

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Journal of Biological Chemistry

15 December 2019

published in

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15 December 2019

volume

278

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15 December 2019

issue

6

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15 December 2019

page(s)

4021-4027

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Polymorphic hydroxylation of Debrisoquine in man.

15 December 2019

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A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation

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Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

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7 Purification and properties of NADPH-Cytochrome P-450 reductase

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Amino acid 305 determines catalytic center accessibility in CYP3A4.

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A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

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