CYP3A5 genotype has an impact on the metabolism of the HIV protease inhibitor saquinavir (Q43946040)

28 November 2017

title

CYP3A5 genotype has an impact on the metabolism of the HIV protease inhibitor saquinavir (English)

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5

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Josephson F

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Allqvist A

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Janabi M

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Sayi J

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Jande M

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Mahindi M

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Bottiger Y

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Bertilsson L

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28 November 2017

language of work or name

English

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publication date

28 February 2007

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Clinical Pharmacology & Therapeutics

28 November 2017

published in

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28 November 2017

volume

81

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28 November 2017

issue

5

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28 November 2017

page(s)

708-712

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Significance of the minor cytochrome P450 3A isoforms.

28 November 2017

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Summary of information on human CYP enzymes: human P450 metabolism data

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The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

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Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

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Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

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Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms

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Tacrolimus dosing in adult lung transplant patients is related to cytochrome P4503A5 gene polymorphism

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CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation

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The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients

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Genotype???phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women

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CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy.

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Association of the CYP3A5 A6986G (CYP3A5*3) polymorphism with saquinavir pharmacokinetics

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Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5.

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Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

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Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial

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Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures

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Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection.

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Enzymatic characteristics of CYP3A5 and CYP3A4: a comparison of in vitro kinetic and drug-drug interaction patterns

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Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study

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CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer

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CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

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7 January 2021

Highly sensitive determination of saquinavir in biological samples using liquid chromatography-tandem mass spectrometry

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7 January 2021

Identifiers

DOI

10.1038/SJ.CLPT.6100117

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28 November 2017

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