Platelet factor 4 impairs the anticoagulant activity of activated protein C. (Q43667908)

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19 January 2020

title

Platelet factor 4 impairs the anticoagulant activity of activated protein C (English)

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19 January 2020

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8

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James S O'Donnell

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19 January 2020

Roger Preston

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19 January 2020

author name string

Sinh Tran

2

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19 January 2020

Jennifer A Johnson

3

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19 January 2020

Fionnuala Ní Áinle

4

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Shona Harmon

5

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Barry White

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Owen P Smith

7

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Björn Dahlbäck

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language of work or name

English

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publication date

6 January 2009

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Journal of Biological Chemistry

19 January 2020

published in

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volume

284

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issue

9

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page(s)

5869-5875

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The anticoagulant protein C pathway

19 January 2020

cites work

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https://api.crossref.org/works/10.1074/JBC.M804703200

21 January 2018

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Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor

21 January 2018

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The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

21 January 2018

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Familial protein S deficiency is associated with recurrent thrombosis

21 January 2018

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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

21 January 2018

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

21 January 2018

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Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

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Inhibition of activated protein C by platelets

21 January 2018

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Platelet factor 4: a chemokine enigma

21 January 2018

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Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va.

21 January 2018

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Multifunctional specificity of the protein C/activated protein C Gla domain.

21 January 2018

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Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.

21 January 2018

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Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C

21 January 2018

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Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

21 January 2018

1 reference

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Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

21 January 2018

1 reference

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The Interaction between the Endothelial Cell Protein C Receptor and Protein C Is Dictated by the γ-Carboxyglutamic Acid Domain of Protein C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M804703200

A chimeric protein C containing the prothrombin Gla domain exhibits increased anticoagulant activity and altered phospholipid specificity.

21 January 2018

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Comparison of naturally occurring vitamin K-dependent proteins: correlation of amino acid sequences and membrane binding properties suggests a membrane contact site

21 January 2018

1 reference

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Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

21 January 2018

1 reference

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Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

21 January 2018

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Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

21 January 2018

1 reference

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Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M804703200

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

21 January 2018

1 reference

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Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M804703200

Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M804703200

21 January 2018

Identifiers

DOI

10.1074/JBC.M804703200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19129181 AND SRC:MED&resulttype=core&format=json

19 January 2020

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