A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma. (Q43601788)

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28 March 2020

title

A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma (English)

1 reference

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28 March 2020

main subject

phase I clinical trial

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1 reference

1

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28 March 2020

Eileen M. O'Reilly

16

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28 March 2020

author name string

Kenneth H Yu

2

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28 March 2020

David Paul Kelsen

3

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28 March 2020

James J Harding

4

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28 March 2020

John S Bomalaski

5

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28 March 2020

Danielle C Glassman

6

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28 March 2020

Christina M Covington

7

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Robin Brenner

8

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Ellen Hollywood

9

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Adalberto Barba

10

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Amanda Johnston

11

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Kay Chia-Wei Liu

12

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Xiaoxing Feng

13

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Marinela Capanu

14

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Ghassan K Abou-Alfa

15

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language of work or name

English

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publication date

18 August 2017

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volume

123

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issue

23

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page(s)

4556-4565

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Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine

28 March 2020

cites work

1 reference

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

21 January 2018

1 reference

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

21 January 2018

1 reference

Metabolism addiction in pancreatic cancer

21 January 2018

1 reference

Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase

21 January 2018

1 reference

Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation

21 January 2018

1 reference

Arginine dependence of tumor cells: targeting a chink in cancer's armor

21 January 2018

1 reference

Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes

21 January 2018

1 reference

Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges

21 January 2018

1 reference

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

21 January 2018

1 reference

Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis

21 January 2018

1 reference

Arginine deprivation as a targeted therapy for cancer

21 January 2018

1 reference

Poly(ethylene glycol) (PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties

21 January 2018

1 reference

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1.

21 January 2018

1 reference

Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer

21 January 2018

1 reference

RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine

21 January 2018

1 reference

Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging

21 January 2018

1 reference

RECIST 1.1 - Standardisation and disease-specific adaptations: Perspectives from the RECIST Working Group

21 January 2018

1 reference

Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

21 January 2018

1 reference

Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial.

21 January 2018

1 reference

A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

21 January 2018

1 reference

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase

21 January 2018

1 reference

Phase I Trial of Arginine Deprivation Therapy with ADI-PEG 20 Plus Docetaxel in Patients with Advanced Malignant Solid Tumors

21 January 2018

1 reference

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/CNCR.30897

1 reference

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28 March 2020

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