Human ARF binds E2F1 and inhibits its transcriptional activity. (Q43583428)

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6 November 2019

title

Human ARF binds E2F1 and inhibits its transcriptional activity (English)

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6 November 2019

3

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6 November 2019

author name string

B Eymin

1

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6 November 2019

L Karayan

2

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6 November 2019

C Brambilla

4

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6 November 2019

E Brambilla

5

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6 November 2019

C J Larsen

6

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6 November 2019

S Gazzéri

7

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6 November 2019

language of work or name

English

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publication date

1 March 2001

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6 November 2019

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6 November 2019

volume

20

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6 November 2019

issue

9

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6 November 2019

page(s)

1033-1041

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p14ARF links the tumour suppressors RB and p53.

6 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

The human protein p19ARF is not detected in hemopoietic human cell lines that abundantly express the alternative β transcript of the p16INK4a/MTS1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

The regulation of E2F by pRB-family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Regulation of cell proliferation by the E2F transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

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p53, the cellular gatekeeper for growth and division

21 January 2018

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

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An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

1 reference

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The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

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Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

p53-independent functions of the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

7 January 2021

The INK4a/ARF tumor suppressor: one gene--two products--two pathways

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

7 January 2021

Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204220

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204220

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11314038 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 November 2019

1030361218

0 references

1 reference