Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2. (Q43511063)

24 November 2017

title

Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2. (English)

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24 November 2017

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Duong LT

1

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24 November 2017

Nakamura I

2

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24 November 2017

Lakkakorpi PT

3

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24 November 2017

Lipfert L

4

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24 November 2017

Bett AJ

5

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24 November 2017

Rodan GA

6

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24 November 2017

language of work or name

English

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publication date

1 December 2000

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Journal of Biological Chemistry

24 November 2017

published in

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24 November 2017

volume

276

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24 November 2017

issue

10

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24 November 2017

page(s)

7484-7492

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Regulation of osteoclast function

24 November 2017

cites work

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Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface

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Integrins and signaling in osteoclast function

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Echistatin is a potent inhibitor of bone resorption in culture

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The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor

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A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo

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RAFTK/Pyk2-mediated cellular signalling

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Signaling through focal adhesion kinase

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Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling

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A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal

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Protein tyrosine kinase PYK2 involved in Ca(2 )-induced regulation of ion channel and MAP kinase functions

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PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase

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RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes

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Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells

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Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

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Tyrosine Phosphorylation of p130Cas Is Involved in Actin Organization in Osteoclasts

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An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

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Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor

21 January 2018

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Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone

21 January 2018

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Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

21 January 2018

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In vitro and in vivo suppression of osteoclast function by adenovirus vector-induced csk gene.

21 January 2018

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Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

21 January 2018

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Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

21 January 2018

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A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

21 January 2018

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Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha

21 January 2018

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

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Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion

21 January 2018

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Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIbbeta 3

21 January 2018

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A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

21 January 2018

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Osteoclasts express high levels of pp60c-src in association with intracellular membranes

21 January 2018

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Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

21 January 2018

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Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M008368200

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24 November 2017

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