Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. (Q43281839)

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scientific article published in September 2009

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English	Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain.	scientific article published in September 2009

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scholarly article

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6 February 2020

Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain (English)

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6 February 2020

Alzheimer's disease

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1

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Hoau-Yan Wang

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6 February 2020

author name string

Andres Stucky

2

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6 February 2020

JingJing Liu

3

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6 February 2020

Changpeng Shen

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6 February 2020

Caryn Trocme-Thibierge

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6 February 2020

Philippe Morain

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6 February 2020

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1 September 2009

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6 February 2020

Journal of Neuroscience

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6 February 2020

29

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6 February 2020

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6 February 2020

10961-10973

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6 February 2020

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

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Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Intraneuronal Abeta42 accumulation in human brain.

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

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beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

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Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

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beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Anti-amyloidogenic activity of tetracyclines: studies in vitro.

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

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Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Increased association of brain protein kinase C with the receptor for activated C kinase-1 (RACK1) in bipolar affective disorder

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https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Cells in human postmortem brain tissue slices remain alive for several weeks in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Long-term regulation of n-methyl-d-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease: evidence of impaired glutamatergic neurotransmission?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Effects of memantine and donepezil on amyloid beta-induced memory impairment in a delayed-matching to position task in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

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beta-amyloid is different in normal aging and in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

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alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Altered response to rTMS in patients with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Soluble Abeta and cognitive function in aged F-344 rats and Tg2576 mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Plaques, tangles, and memory loss in mouse models of neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Cortical plasticity in Alzheimer's disease in humans and rodents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement of contextual memory by S 24795 in aged mice: comparison with memantine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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The partial alpha7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's beta-amyloid peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative effects of the alpha7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why Is the C-terminus of Abeta(1-42) more unfolded than that of Abeta(1-40)? Clues from hydrophobic interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet-activating factor: diminished acetylcholine release from rat brain slices is mediated by a Gi protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical NMDA receptor properties and membrane fluidity are altered in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A

1 reference

https://pubmed.ncbi.nlm.nih.gov/19726654

12 December 2020

based on heuristic

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Identifiers

10.1523/JNEUROSCI.6088-08.2009

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19726654 AND SRC:MED&resulttype=core&format=json

6 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19726654 AND SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19726654 AND SRC:MED&resulttype=core&format=json

6 February 2020

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