The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization (Q43211428)

16 November 2017

title

The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization (English)

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Mariantonietta Capristo

Mariantonietta Capristo

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Michela Rugolo

Michela Rugolo

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Valerio Carelli

Valerio Carelli

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Giovanni Tallini

Giovanni Tallini

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author name string

Anna Maria Porcelli

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Anna Ghelli

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Giovanna Cenacchi

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Lucia Fiammetta Pennisi

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Isabella Morra

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Enrica Ciccarelli

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Antonio Melcarne

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Anna Bartoletti-Stella

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Nunzio Salfi

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Marcella Attimonelli

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Giovanni Romeo

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Giuseppe Gasparre

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publication date

22 December 2009

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published in

Human Molecular Genetics

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volume

19

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issue

6

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page(s)

1019-1032

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Mitochondrial disorders in the nervous system

16 November 2017

cites work

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A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

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Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

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Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma

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An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells

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Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

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Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma

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Lack of complex I is associated with oncocytic thyroid tumours

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma

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Mitochondrial complex I is deficient in renal oncocytomas

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Transcriptional profiling reveals coordinated up-regulation of oxidative metabolism genes in thyroid oncocytic tumors

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Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors.

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Mitochondria and cancer

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Energy metabolism in tumor cells

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mtDNA tree Build 17 (18 Feb 2016)

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Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

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The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.

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Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants

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Human mtDNA site-specific variability values can act as haplogroup markers

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Identifiers

DOI

10.1093/HMG/DDP566

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16 November 2017

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