Methotrexate--how does it really work? (Q43144564)

14 November 2017

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title

Methotrexate--how does it really work? (English)

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14 November 2017

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Edwin S L Chan

1

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14 November 2017

Bruce N Cronstein

series ordinal

2

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14 November 2017

language of work or name

English

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publication date

1 March 2010

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Nature Reviews Rheumatology

14 November 2017

published in

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14 November 2017

volume

6

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14 November 2017

issue

3

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14 November 2017

page(s)

175-178

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Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study

14 November 2017

cites work

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Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis

31 March 2020

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Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies

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Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study

31 March 2020

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Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells

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Antiproliferative effects of methotrexate on peripheral blood mononuclear cells

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In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine

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Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides

31 March 2020

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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

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Adenosine potentiates mediator release from human lung mast cells

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Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat.

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The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

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Methotrexate modulates the kinetics of adenosine in humans in vivo

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Adenosine and methotrexate polyglutamate concentrations in patients with juvenile arthritis.

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Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

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Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis. Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression

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The effect of liposomally conjugated methotrexate upon mediator release from human peripheral blood monocytes

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Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression

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Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis

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Methotrexate action in rheumatoid arthritis: stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells

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Effect of antiarthritic drugs on the enhanced interleukin-1 (IL-1) production by macrophages from adjuvant-induced arthritic (AA) rats

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The effects of methotrexate on the production and activity of interleukin-1

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Reduction of leukocyte and interleukin-1 beta concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate

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Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate

31 March 2020

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Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates

31 March 2020

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Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate

31 March 2020

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Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.

31 March 2020

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Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis

31 March 2020

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Coffee, tea, and mortality

31 March 2020

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Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis

31 March 2020

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Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors

31 March 2020

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12 December 2020

Discrepancy between 3H-thymidine uptake and cell cycle studies in stimulated lymphocyte cultures treated with methotrexate

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12 December 2020

Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation

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12 December 2020

Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: A mechanism for methotrexate-induced nodulosis in rheumatoid arthritis

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12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2010.5

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14 November 2017

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