Computational design of a water-soluble analog of phospholamban (Q43137315)

14 November 2017

Computational design of a water-soluble analog of phospholamban (English)

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14 November 2017

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4

William F DeGrado

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14 November 2017

1

Avram M Slovic

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14 November 2017

Christopher M Summa

2

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PMC publication ID

2312418

14 November 2017

James D Lear

series ordinal

3

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14 November 2017

1 February 2003

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14 November 2017

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14 November 2017

12

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14 November 2017

2

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14 November 2017

337-348

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Comparison of helix interactions in membrane and soluble alpha-bundle proteins.

14 November 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Conversion of phospholamban into a soluble pentameric helical bundle

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Analysis of a data set of paired uncomplexed protein structures: new metrics for side-chain flexibility and model evaluation.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Use of a new label, (13)==(18)O, in the determination of a structural model of phospholamban in a lipid bilayer. Spatial restraints resolve the ambiguity arising from interpretations of mutagenesis data.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

A polar, solvent-exposed residue can be essential for native protein structure

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Modeling transmembrane helical oligomers

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Phospholamban inhibitory function is activated by depolymerization

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Comparative studies of cardiac and skeletal sarcoplasmic reticulum ATPases. Effect of a phospholamban antibody on enzyme activation by Ca2 .

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

A thermodynamic scale for leucine zipper stability and dimerization specificity: e and g interhelical interactions

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Elucidating the folding problem of helical peptides using empirical parameters. II. Helix macrodipole effects and rational modification of the helical content of natural peptides.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Solution structure of the cytoplasmic domain of phopholamban: phosphorylation leads to a local perturbation in secondary structure

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Functional reconstitution of recombinant phospholamban with rabbit skeletal Ca(2 )-ATPase

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Regulation of calcium transport by the ATPase-phospholamban system

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Phosphorylation-induced mobility shift in phospholamban in sodium dodecyl sulfate-polyacrylamide gels. Evidence for a protein structure consisting of multiple identical phosphorylatable subunits

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Factors that modify the molecular size of phospholamban, the 23,000-dalton cardiac sarcoplasmic reticulum phosphoprotein

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Complete complementary DNA-derived amino acid sequence of canine cardiac phospholamban

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Characterization of structural unit of phospholamban by amino acid sequencing and electrophoretic analysis

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Purification and characterization of phospholamban from canine cardiac sarcoplasmic reticulum

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Phospholamban forms Ca2 -selective channels in lipid bilayers.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Hydrophobic organization of membrane proteins

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Secondary structure of detergent-solubilized phospholamban, a phosphorylatable, oligomeric protein of cardiac sarcoplasmic reticulum

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Large differences in the helix propensities of alanine and glycine

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Prediction of protein side-chain conformation by packing optimization.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Molecular weight determination of phospholamban oligomer in the presence of sodium dodecyl sulfate: application of low-angle laser light scattering photometry

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Phospholamban mediates the beta-adrenergic-enhanced Ca2 uptake in mammalian ventricular myocytes

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Regulation of the calcium ion pump of sarcoplasmic reticulum: Reversible inhibition by phospholamban and by the calmodulin binding domain of the plasma membrane calcium pump

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Proteolytic cleavage of phospholamban purified from canine cardiac sarcoplasmic reticulum vesicles. Generation of a low resolution model of phospholamban structure.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Stabilization of proteins by rational design of alpha-helix stability using helix/coil transition theory.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Elucidating the folding problem of helical peptides using empirical parameters

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2312418

Partial Volumes and Compressibilities of Extended Polypeptide Chains in Aqueous Solution: Additivity Scheme and Implication of Protein Unfolding at Normal and High Pressure

15 August 2018

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12 December 2020

Phosphorylation-induced structural change in phospholamban and its mutants, detected by intrinsic fluorescence

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12 December 2020

A buried polar interaction imparts structural uniqueness in a designed heterodimeric coiled coil

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12 December 2020

Residues 2-25 of phospholamban are insufficient to inhibit Ca2 transport ATPase of cardiac sarcoplasmic reticulum

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12 December 2020

A leucine zipper stabilizes the pentameric membrane domain of phospholamban and forms a coiled-coil pore structure

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12 December 2020

The nature of the modulation of Ca2 transport as studied by reconstitution of cardiac sarcoplasmic reticulum

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12 December 2020

Do more complex organisms have a greater proportion of membrane proteins in their genomes?

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12 December 2020

Helix packing in membrane proteins

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12 December 2020

Mutation and phosphorylation change the oligomeric structure of phospholamban in lipid bilayers

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12 December 2020

Correlation between calmodulin-dependent increase in the rate of calcium transport and calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum. Characterization of calmodulin-dependent phosphorylation

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12 December 2020

Computational de novo design, and characterization of an A(2)B(2) diiron protein

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12 December 2020

D(n)-symmetrical tertiary templates for the design of tubular proteins

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12 December 2020

Reexamination of the role of the leucine/isoleucine zipper residues of phospholamban in inhibition of the Ca2 pump of cardiac sarcoplasmic reticulum

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12 December 2020

Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains

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12 December 2020

Maximal inhibition of SERCA2 Ca(2 ) affinity by phospholamban in transgenic hearts overexpressing a non-phosphorylatable form of phospholamban

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12 December 2020

Characterization of the molecular form of cardiac phospholamban

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12 December 2020

Proteolytic activation of the canine cardiac sarcoplasmic reticulum calcium pump

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12 December 2020

Thermodynamic analysis of a designed three-stranded coiled coil

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12 December 2020

Structural model of the phospholamban ion channel complex in phospholipid membranes

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12 December 2020

Toward a high-resolution structure of phospholamban: design of soluble transmembrane domain mutants

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12 December 2020

Conformation of the cytoplasmic domain of phospholamban by NMR and CD

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12 December 2020

Evidence for a phosphorylation-induced conformational change in phospholamban cytoplasmic domain by CD analysis

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12 December 2020

Conformational effects of serine phosphorylation in phospholamban peptides

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12 December 2020

Stimulation of bovine cardiac sarcoplasmic reticulum Ca2 pump and blocking of phospholamban phosphorylation and dephosphorylation by a phospholamban monoclonal antibody

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12 December 2020

Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2 )-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban.

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12 December 2020

Identifiers

DOI

10.1110/PS.0226603

1 reference

14 November 2017

1 reference

PMC publication ID

2312418

14 November 2017

PubMed publication ID

12538897

1 reference

PMC publication ID

2312418