Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. (Q43121593)

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23 January 2020

title

Activin/Nodal signalling maintains pluripotency by controlling Nanog expression (English)

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23 January 2020

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5

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23 January 2020

Ludovic Vallier

1

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23 January 2020

Peter J Rugg-Gunn

10

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23 January 2020

author name string

Sasha Mendjan

2

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23 January 2020

Stephanie Brown

3

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23 January 2020

Zhenzhi Chng

4

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23 January 2020

Lucy E Smithers

6

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23 January 2020

Matthew W B Trotter

7

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23 January 2020

Candy H-H Cho

8

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23 January 2020

Amelie Martinez

9

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23 January 2020

Gabrielle Brons

11

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23 January 2020

Roger A Pedersen

12

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23 January 2020

language of work or name

English

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publication date

11 March 2009

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23 January 2020

number of pages

11

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inferred from page(s)

published in

Development

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volume

136

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issue

8

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23 January 2020

page(s)

1339-1349

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NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs

23 January 2020

cites work

1 reference

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25 May 2018

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Nanog safeguards pluripotency and mediates germline development

25 May 2018

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25 May 2018

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Derivation of pluripotent epiblast stem cells from mammalian embryos

25 May 2018

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New cell lines from mouse epiblast share defining features with human embryonic stem cells

25 May 2018

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Tissue-specific transcriptional regulation has diverged significantly between human and mouse

25 May 2018

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Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

25 May 2018

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Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo

25 May 2018

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Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features

25 May 2018

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Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.

25 May 2018

1 reference

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Core transcriptional regulatory circuitry in human embryonic stem cells

25 May 2018

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Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages

25 May 2018

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Neural induction: old problem, new findings, yet more questions

25 May 2018

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Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells

25 May 2018

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Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway.

25 May 2018

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Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.

25 May 2018

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BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning

25 May 2018

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Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human

25 May 2018

1 reference

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Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo

25 May 2018

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BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

25 May 2018

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Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells

25 May 2018

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The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

25 May 2018

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25 May 2018

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25 May 2018

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TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

25 May 2018

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Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation

15 August 2018

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Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.

15 August 2018

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BMP4 initiates human embryonic stem cell differentiation to trophoblast

15 August 2018

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12 December 2020

Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro

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12 December 2020

Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning

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12 December 2020

Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm

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12 December 2020

Identifiers

DOI

10.1242/DEV.033951

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19279133 AND SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19279133 AND SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

19279133

1 reference