Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. (Q42966822)

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title

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening (English)

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7

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David M. Reif

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John F. Wambaugh

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Russell S. Thomas

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Daniel M Rotroff

1

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Melvin E. Andersen

8

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Richard S. Judson

9

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Matthew T Martin

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3

David J Dix

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Keith A Houck

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2

Barbara A Wetmore

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Mark A Sochaski

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Harvey J Clewell

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author name string

Stephen S Ferguson

4

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Cornelia M Smith

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Robert J Kavlock

12

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Frank Boellmann

13

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publication date

16 July 2010

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8 February 2020

published in

Toxicological Sciences

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volume

117

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issue

2

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page(s)

348-358

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Toxicity testing in the 21st century: bringing the vision to life

8 February 2020

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Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation

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Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations

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The toxicity data landscape for environmental chemicals

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Toxicity testing in the 21st century: implications for human health risk assessment

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Absorption and Excretion of 2,4-Dichlorophenoxyacetic Acid in Man

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Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database

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Comparison of models for the estimation of biological partition coefficients

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Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution

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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

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The fate of 2,4-dichlorophenoxyacetic acid (2,4-D) following oral administration to man.

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Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling

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Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling

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Metabolism and kinetics of bisphenol a in humans at low doses following oral administration

21 January 2018

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12 December 2020

Toxicity testing gets a makeover

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Identifiers

DOI

10.1093/TOXSCI/KFQ220

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PubMed publication ID

20639261

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