Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation. (Q42958588)

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8 February 2020

title

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation (English)

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8 February 2020

Silvio Bicciato

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8 February 2020

Paolo Puccetti

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Claudia Volpi

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8 February 2020

Francesco Fazio

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Serena Notartomaso

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8 February 2020

Carmine Vacca

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8 February 2020

Carla L Busceti

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8 February 2020

Giuseppe Battaglia

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Valeria Maria Gloria Bruno

8 February 2020

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Ferdinando Nicoletti

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author name string

Maria C Fioretti

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8 February 2020

Ursula Grohmann

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8 February 2020

Roberto Di Marco

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language of work or name

English

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publication date

25 July 2010

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8 February 2020

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8 February 2020

volume

16

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issue

8

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8 February 2020

page(s)

897-902

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Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation

8 February 2020

cites work

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Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

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The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

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Reflex control of immunity

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 T helper cells

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation.

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

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Glutamate excitotoxicity in a model of multiple sclerosis

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Th17 cells in autoimmune demyelinating disease.

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Neurotransmitters in cerebrospinal fluid reflect pathological activity

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

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Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS

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IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice

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The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis.

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Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis

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Glutamate-mediated glial injury: mechanisms and clinical importance

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Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

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Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats

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12 December 2020

Expression of metabotropic glutamate receptors in murine thymocytes and thymic stromal cells

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12 December 2020

Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor

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12 December 2020

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

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12 December 2020

Inhibitory role for GABA in autoimmune inflammation

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12 December 2020

Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.

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Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

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Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

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Dendritic cells and the control of immunity

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Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation.

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Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas

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T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis

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Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.

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Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Elaborate interactions between the immune and nervous systems

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Pharmacology and functions of metabotropic glutamate receptors

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IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

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Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures.

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Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury

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A-MADMAN: annotation-based microarray data meta-analysis tool

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The role of dendritic cells in CNS autoimmunity

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