Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation. (Q42937091)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19901081 AND SRC:MED&resulttype=core&format=json

12 February 2020

title

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation (English)

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12 February 2020

4

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12 February 2020

Peter H L Krijger

series ordinal

1

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12 February 2020

author name string

Petra Langerak

series ordinal

2

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12 February 2020

Paul C M van den Berk

series ordinal

3

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12 February 2020

language of work or name

English

0 references

publication date

9 November 2009

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Journal of Experimental Medicine

12 February 2020

published in

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12 February 2020

volume

206

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12 February 2020

issue

12

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12 February 2020

page(s)

2603-2611

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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

12 February 2020

cites work

1 reference

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PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.

27 May 2018

1 reference

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Proteasomal degradation restricts the nuclear lifespan of AID

27 May 2018

1 reference

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DNA polymerases in adaptive immunity

27 May 2018

1 reference

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A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Molecular mechanisms of antibody somatic hypermutation.

27 May 2018

1 reference

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DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

A role for PCNA ubiquitination in immunoglobulin hypermutation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice

27 May 2018

1 reference

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Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

27 May 2018

1 reference

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Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA.

27 May 2018

1 reference

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The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function

27 May 2018

1 reference

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Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

DNA polymerase kappa deficiency does not affect somatic hypermutation in mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Inefficient bypass of an abasic site by DNA polymerase eta.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Deoxycytidyl transferase activity of yeast REV1 protein

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806606

Send in the Clamps: Control of DNA Translesion Synthesis in Eukaryotes

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19901081

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20091707

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19901081 AND SRC:MED&resulttype=core&format=json

12 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19901081 AND SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

19901081

1 reference