Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked (Q42936280)

11 November 2017

Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked (English)

1 reference

11 November 2017

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json

12 June 2020

Rosalina Wisastra

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Rosalina Wisastra

series ordinal

1

1 reference

11 November 2017

17 July 2014

1 reference

11 November 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json

12 June 2020

volume

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json

12 June 2020

issue

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

1500-1521

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

12 June 2020

copyright license

start time

17 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Leukotriene B4 Augments and Restores FcγRs-dependent Phagocytosis in Macrophages

27 May 2018

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Inhibitors of the 5-lipoxygenase pathway in atherosclerosis

27 May 2018

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Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids

27 May 2018

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27 May 2018

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27 May 2018

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Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription

27 May 2018

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27 May 2018

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12R-lipoxygenase deficiency disrupts epidermal barrier function

27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase

27 May 2018

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5-Lipoxygenase: Cellular Biology and Molecular Pharmacology

27 May 2018

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27 May 2018

5-lipoxygenase and FLAP

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27 May 2018

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Subcellular Localization and Tumor-suppressive Functions of 15-Lipoxygenase 2 (15-LOX2) and Its Splice Variants

27 May 2018

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Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells

27 May 2018

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15-lipoxygenase: a Janus enzyme?

27 May 2018

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IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines

27 May 2018

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Enzymes and receptors in the leukotriene cascade

27 May 2018

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Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

27 May 2018

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Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

27 May 2018

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The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation

27 May 2018

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15(S)-HETE modulates LTB(4) production and neutrophil chemotaxis in chronic bronchitis

27 May 2018

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

27 May 2018

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The molecular biology and regulation of 5-lipoxygenase

27 May 2018

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Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

27 May 2018

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Antileukotriene agents in asthma: the dart that kills the elephant?

27 May 2018

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Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites.

27 May 2018

1 reference

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The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

27 May 2018

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New insights from spectroscopy into the structure/function relationships of lipoxygenases

27 May 2018

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Discovery of a second 15S-lipoxygenase in humans

27 May 2018

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The use of 5-lipoxygenase inhibitors and leukotriene receptor antagonists in the treatment of chronic asthma

27 May 2018

1 reference

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5(S),15(S)-dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: dual specificity of 5-lipoxygenase towards endogenous and exogenous precursors.

27 May 2018

1 reference

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Criteria for the identification of non-redox inhibitors of 5-lipoxygenase

27 May 2018

1 reference

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Lipoxin biosynthesis and its impact in inflammatory and vascular events

27 May 2018

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27 May 2018

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The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses

27 May 2018

1 reference

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Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

27 May 2018

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Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response

27 May 2018

1 reference

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Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea

27 May 2018

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L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

27 May 2018

2 references

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27 May 2018

12 December 2020

Basic local alignment search tool

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Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts

27 May 2018

1 reference

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Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells

27 May 2018

1 reference

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The molecular biology of mammalian arachidonic acid metabolism

27 May 2018

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(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity

27 May 2018

1 reference

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5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors

27 May 2018

1 reference

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Designing therapeutically effective 5-lipoxygenase inhibitors

27 May 2018

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Physiochemical characterization of ATP binding to human 5-lipoxygenase.

27 May 2018

1 reference

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Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor

27 May 2018

1 reference

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Montelukast: more than a cysteinyl leukotriene receptor antagonist?

16 August 2018

1 reference

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Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.

16 August 2018

1 reference

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Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.

16 August 2018

1 reference

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Urinary leukotriene E4 excretion: a biomarker of inflammatory bowel disease activity

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma

16 August 2018

1 reference

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Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid

16 August 2018

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Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Leukotriene B(4) promotes reactive oxidant generation and leukocyte adherence during acute hypoxia

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Regulation of 15-lipoxygenase isozymes and mucin secretion by cytokines in cultured normal human bronchial epithelial cells

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

(R)-( )-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Leukotriene A5 is a substrate and an inhibitor of rat and human neutrophil LTA4 hydrolase

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190552

Involvement of 15-lipoxygenase in the inflammatory arthritis

16 August 2018

1 reference

12 December 2020

Structural requirements for the binding of fatty acids to 5-lipoxygenase-activating protein

1 reference

12 December 2020

2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity

1 reference

12 December 2020

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

1 reference

12 December 2020

High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis

1 reference

12 December 2020

Oral leukotriene inhibitor (MK-886) blocks allergen-induced airway responses

1 reference

12 December 2020

Efficacy of zileuton controlled-release tablets administered twice daily in the treatment of moderate persistent asthma: a 3-month randomized controlled study

1 reference

12 December 2020

In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis

1 reference

12 December 2020

Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds

1 reference

12 December 2020

Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors

1 reference

12 December 2020

Δ9-Tetrahydrocannabinol and Its Major Metabolite Δ9-Tetrahydrocannabinol-11-oic Acid as 15-Lipoxygenase Inhibitors

1 reference

12 December 2020

N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase

1 reference

12 December 2020

12-hydroperoxyeicosatetraenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase

1 reference

12 December 2020

Induction period in the lipoxidase-catalyzed oxidation of linoleic acid and its abolition by substrate peroxide

1 reference

12 December 2020

15-Lipoxygenase promotes chronic hypoxia-induced pulmonary artery inflammation via positive interaction with nuclear factor-κB

1 reference

12 December 2020

Identifiers

DOI

10.3390/CANCERS6031500

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

25037020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25037020 AND SRC:MED&resulttype=core&format=json