Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. (Q42911689)

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scientific article published on 13 November 2009

Language	Label	Description	Also known as
English	Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.	scientific article published on 13 November 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. (English)

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

3

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Europe PubMed Central

PMC publication ID

11 November 2017

Stephen L Garland

object named as

Stephen L Garland

5

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author name string

Philip S Miller

1

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Europe PubMed Central

PMC publication ID

11 November 2017

James Barwell

2

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Europe PubMed Central

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11 November 2017

Mark J Wigglesworth

4

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Europe PubMed Central

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11 November 2017

Dan Donnelly

6

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11 November 2017

language of work or name

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publication date

13 November 2009

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11 November 2017

Biochemical and Biophysical Research Communications

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Europe PubMed Central

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11 November 2017

391

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Europe PubMed Central

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11 November 2017

1

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11 November 2017

437-442

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Europe PubMed Central

PMC publication ID

11 November 2017

pA, a new scale for the measurement of drug antagonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Crystal structure of the human receptor activity-modifying protein 1 extracellular domain

1 reference

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27 May 2018

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

1 reference

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27 May 2018

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-relate

1 reference

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27 May 2018

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

1 reference

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27 May 2018

Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Novel receptor partners and function of receptor activity-modifying proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

A human orphan calcitonin receptor-like structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2824848

27 May 2018

A new calcitonin-receptor-like sequence in rat pulmonary blood vessels

1 reference

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16 August 2018

CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19914210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-r

1 reference

https://pubmed.ncbi.nlm.nih.gov/19914210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and pharmacological characterization of domains involved in binding of CGRP receptor antagonists to the calcitonin-like receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19914210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BBRC.2009.11.076

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

ResearchGate publication ID

0 references

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