Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors. (Q42909234)

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scientific article published on 27 November 2009

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English	Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors.	scientific article published on 27 November 2009

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scholarly article

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12 February 2020

Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors (English)

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12 February 2020

Ivan B Yanachkov

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12 February 2020

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Hung Chang

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12 February 2020

Alan D Michelson

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12 February 2020

YouFu Li

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12 February 2020

M R Barnard

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12 February 2020

George E Wright

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12 February 2020

Andrew L Frelinger

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12 February 2020

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27 November 2009

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12 February 2020

Thrombosis Research

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12 February 2020

125

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12 February 2020

2

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12 February 2020

159-165

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12 February 2020

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists

1 reference

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P2Y12 antagonism: promises and challenges

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Nucleotide receptor signaling in platelets

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Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling

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Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor.

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27 May 2018

Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation

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Emerging roles for P2X1 receptors in platelet activation

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Identification and quantification of diadenosine polyphosphate concentrations in human plasma.

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Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases

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A novel assay for determination of diadenosine polyphosphates in human platelets: studies in normotensive subjects and in patients with essential hypertension

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Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist

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Diadenosine polyphosphate receptors. from rat and guinea-pig brain to human nervous system.

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Effects of diadenosine polyphosphates (Ap(n)As) and adenosine polyphospho guanosines (Ap(n)Gs) on rat mesenteric artery P2X receptor ion channels

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The effects of diadenosine polyphosphates on the cardiovascular system

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Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate

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Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets

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Purinoceptor-evoked calcium signalling in human platelets

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The interaction of diadenosine polyphosphates with P2x-receptors in the guinea-pig isolated vas deferens

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Vascular actions of diadenosine phosphates

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27 May 2018

P1,P4-dithio-P2,P3-monochloromethylene diadenosine 5',5'''-P1,P4-tetraphosphate: a novel antiplatelet agent

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Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor

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Platelet aggregation monitored in a 96 well microplate reader is useful for evaluation of platelet agonists and antagonists

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Abundant amounts of diadenosine 5′,5‴-P1,P4-tetraphosphate are present and releasable, but metabolically inactive, in human platelets

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Analogues of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) as potential anti-platelet-aggregation agents

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Antithrombotic effect of beta,beta'-monochloromethylene diadenosine 5',5"'-P1,P4-tetraphosphate

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Presence of diadenosine 5',5''' -P1, P4-tetraphosphate (Ap4A) in mamalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator"

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Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets.

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Activity of diadenosine polyphosphates at P2Y receptors stably expressed in 1321N1 cells

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1 reference

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Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19945153

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Diadenosine 5',5'''-P1,P4-tetraphosphate, a potential antithrombotic agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19945153

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Inhibition of platelet aggregation and the platelet release reaction by α, ω diadenosine polyphosphates

1 reference

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Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

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The presence of diadenosine 5′,5‴-P 1 ,P 3 -triphosphate (Ap 3 A) in human platelets

1 reference

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Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP

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Measuring platelet aggregation with microplate reader. A new technical approach to platelet aggregation studies

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Flow cytometric kinetic assay of calcium mobilization in whole blood platelets using Fluo-3 and CD41

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Identifiers

10.1016/J.THROMRES.2009.11.006

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19945153 AND SRC:MED&resulttype=core&format=json

12 February 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19945153 AND SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

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12 February 2020

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