Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex. (Q42836856)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23734661 AND SRC:MED&resulttype=core&format=json

2 March 2020

title

Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex (English)

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2 March 2020

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3

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2 March 2020

Andrey Komissarov

series ordinal

5

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2 March 2020

1

Galina Florova

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2 March 2020

4

Steven Idell

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2 March 2020

author name string

Sophia Karandashova

series ordinal

2

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2 March 2020

language of work or name

English

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publication date

25 June 2013

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2 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23734661 AND SRC:MED&resulttype=core&format=json

2 March 2020

volume

52

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2 March 2020

issue

27

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2 March 2020

page(s)

4697-4709

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Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpin

2 March 2020

cites work

1 reference

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Intrapleural adenoviral delivery of human plasminogen activator inhibitor-1 exacerbates tetracycline-induced pleural injury in rabbits

27 May 2018

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The Biochemistry, Physiology and Pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo.

27 May 2018

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PAI-1, progress in understanding the clinical problem and its aetiology

27 May 2018

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Effects of Extracellular DNA on Plasminogen Activation and Fibrinolysis

27 May 2018

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Therapeutic Value of Small Molecule Inhibitor to Plasminogen Activator Inhibitor–1 for Lung Fibrosis

27 May 2018

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PAI-1: An Integrator of Cell Signaling and Migration

27 May 2018

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Structural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1

27 May 2018

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Plasminogen activator inhibitor‐1 inhibits factor VIIa bound to tissue factor

27 May 2018

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The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis

27 May 2018

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A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates

27 May 2018

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Regulation of intrapleural fibrinolysis by urokinase-alpha-macroglobulin complexes in tetracycline-induced pleural injury in rabbits

27 May 2018

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PAI-1 - a potential therapeutic target in cancer

27 May 2018

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Targeting plasminogen activator inhibitor-1: role in cell signaling and the biology of domain-specific knock-in mice

27 May 2018

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Plasminogen activator inhibitor 1 promotes a poor prognosis in sepsis-induced disseminated intravascular coagulation.

27 May 2018

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Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal.

27 May 2018

1 reference

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How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration

27 May 2018

1 reference

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Plasminogen activator inhibitor type-1 (part one): basic mechanisms, regulation, and role for thromboembolic disease

27 May 2018

1 reference

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Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

27 May 2018

1 reference

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Role of vitronectin and its receptors in haemostasis and vascular remodeling

27 May 2018

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The P6−P2 Region of Serpins Is Critical for Proteinase Inhibition and Complex Stability

27 May 2018

1 reference

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A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism

27 May 2018

1 reference

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On the size of the active site in proteases. I. Papain

27 May 2018

1 reference

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Plasminogen activator inhibitors--a review

27 May 2018

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Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1

27 May 2018

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Abnormalities of pathways of fibrin turnover in the human pleural space

27 May 2018

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Thrombin neutralizes plasminogen activator inhibitor 1 (PAI-1) that is complexed with vitronectin in the endothelial cell matrix

27 May 2018

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Structural requirements for the extracellular interaction of plasminogen activator inhibitor 1 with endothelial cell matrix-associated vitronectin

27 May 2018

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Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties

27 May 2018

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Compartment-specific expression of plasminogen activator inhibitor-1 correlates with severity/outcome of murine polymicrobial sepsis

27 May 2018

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Redirection of the reaction between activated protein C and a serpin to the substrate pathway

16 August 2018

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Modulation of serpin reaction through stabilization of transient intermediate by ligands bound to alpha-helix F.

16 August 2018

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Protonation state of a single histidine residue contributes significantly to the kinetics of the reaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator

16 August 2018

1 reference

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The contribution of the exosite residues of plasminogen activator inhibitor-1 to proteinase inhibition.

16 August 2018

1 reference

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Single-chain urokinase alone or complexed to its receptor in tetracycline-induced pleuritis in rabbits

16 August 2018

1 reference

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Mechanisms of conversion of plasminogen activator inhibitor 1 from a suicide inhibitor to a substrate by monoclonal antibodies

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855604

The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855604

Directing sequence-specific proteolysis to new targets. The influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and urokinase-type plasminogen activator.

16 August 2018

1 reference

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Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: relationship to multiple organ dysfunction syndrome

16 August 2018

1 reference

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Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1

16 August 2018

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12 December 2020

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin)

1 reference

12 December 2020

Early inhibition of activated fibrinolysis predicts microbial infection, shock and mortality in febrile medical patients

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12 December 2020

The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure

1 reference

12 December 2020

Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma

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12 December 2020

Maximal PAI-1 inhibition in vivo requires neutralizing antibodies that recognize and inhibit glycosylated PAI-1

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12 December 2020

1 reference

12 December 2020

Time-resolved polarized fluorescence spectroscopy studies of plasminogen activator inhibitor type 1: conformational changes of the reactive center upon interactions with target proteases, vitronectin and heparin

1 reference

12 December 2020

High concentrations of active plasminogen activator inhibitor-1 in porcine coronary artery thrombi

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12 December 2020

Vitronectin governs the interaction between plasminogen activator inhibitor 1 and tissue-type plasminogen activator

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12 December 2020

Elucidation of the epitope of a latency-inducing antibody: identification of a new molecular target for PAI-1 inhibition

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12 December 2020

Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin

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12 December 2020

Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay

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12 December 2020

Accelerated conversion of human plasminogen activator inhibitor-1 to its latent form by antibody binding

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12 December 2020

Determination of the vitronectin binding site on plasminogen activator inhibitor 1 (PAI‐1)

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12 December 2020

Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin

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12 December 2020

TAFI and PAI-1 levels in human sepsis

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12 December 2020

Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C

1 reference

12 December 2020

Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers

1 reference

12 December 2020

Resolution of Michaelis complex, acylation, and conformational change steps in the reactions of the serpin, plasminogen activator inhibitor-1, with tissue plasminogen activator and trypsin

1 reference

12 December 2020

The composition of complexes between plasminogen activator inhibitor 1, vitronectin and either thrombin or tissue-type plasminogen activator

1 reference

12 December 2020

Disseminated intravascular coagulation in sepsis

1 reference

12 December 2020

Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases

1 reference

12 December 2020

Synthesis and secretion of plasminogen activator inhibitor 1 by human endothelial cells in vitro. Effect of active site mutagenized tissue-type plasminogen activator

1 reference

12 December 2020

Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions

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12 December 2020

Identifiers

DOI

10.1021/BI400470S

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23734661 AND SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23734661 AND SRC:MED&resulttype=core&format=json

2 March 2020

PubMed publication ID

23734661

1 reference