An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. (Q42834187)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14612455 AND SRC:MED&resulttype=core&format=json

21 December 2019

title

An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis (English)

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21 December 2019

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Christopher J. Lengner

3

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21 December 2019

Ezra Burstein

2

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21 December 2019

author name string

Heather A Steinman

1

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21 December 2019

Joseph Gosselin

4

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21 December 2019

German Pihan

5

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21 December 2019

Colin S Duckett

6

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21 December 2019

Stephen N Jones

7

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21 December 2019

language of work or name

English

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publication date

10 November 2003

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Journal of Biological Chemistry

21 December 2019

published in

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21 December 2019

volume

279

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21 December 2019

issue

6

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21 December 2019

page(s)

4877-4886

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Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

21 December 2019

cites work

1 reference

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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Mapping of the p53 and mdm-2 Interaction Domains

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

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The Mdm2 oncoprotein interacts with the cell fate regulator Numb

21 January 2018

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A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2

21 January 2018

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Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation

21 January 2018

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Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

21 January 2018

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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

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Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

21 January 2018

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Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma

21 January 2018

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Alternative and aberrant splicing of MDM2 mRNA in human cancer

21 January 2018

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Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

21 January 2018

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Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.

21 January 2018

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Genomic organization of the mouse double minute 2 gene

21 January 2018

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ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

21 January 2018

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c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

21 January 2018

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Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB

21 January 2018

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Identification and characterization of nuclear factor kappaB binding sites in the murine bcl-x promoter.

21 January 2018

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NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

21 January 2018

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

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NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

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MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia

21 January 2018

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The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression.

21 January 2018

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

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21 January 2018

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Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice

21 January 2018

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The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

21 January 2018

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Nf-kappa B, chemokine gene transcription and tumour growth

21 January 2018

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Role of NF-κB in p53-mediated programmed cell death

21 January 2018

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An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M305966200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14612455 AND SRC:MED&resulttype=core&format=json

21 December 2019

1 reference