Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel (Q42738744)

6 November 2017

Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel (English)

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6 November 2017

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Michelle Yen

1

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6 November 2017

Ludmila A Lokteva

series ordinal

2

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6 November 2017

Richard S Lewis

series ordinal

3

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6 November 2017

language of work or name

English

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publication date

1 November 2016

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6 November 2017

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6 November 2017

111

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6 November 2017

9

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6 November 2017

1897-1907

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α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels.

6 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2 -dependent inactivation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Orai1 pore residues control CRAC channel inactivation independently of calmodulin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Store-Operated Calcium Channels.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Molecular biophysics of Orai store-operated Ca2 channels.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

On the stoichiometry of resting and activated CRAC channels.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

How many Orai's does it take to make a CRAC channel?

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Gated regulation of CRAC channel ion selectivity by STIM1.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Stoichiometric requirements for trapping and gating of Ca2 release-activated Ca2 (CRAC) channels by stromal interaction molecule 1 (STIM1).

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

A practical guide to the preparation of Ca(2 ) buffers

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Molecular basis of calcium signaling in lymphocytes: STIM and ORAI

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Pore architecture of the ORAI1 store-operated calcium channel.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Structural determinants of ion permeation in CRAC channels

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

STIM protein coupling in the activation of Orai channels.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2 channel function in the heterozygous condition.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Functional stoichiometry of the unitary calcium-release-activated calcium channel

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Orai1 subunit stoichiometry of the mammalian CRAC channel pore.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Mapping the interacting domains of STIM1 and Orai1 in Ca2 release-activated Ca2 channel activation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Ca2 store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Monovalent cation permeability and Ca(2 ) block of the store-operated Ca(2 ) current I(CRAC )in rat basophilic leukemia cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Potentiation and inhibition of Ca(2 ) release-activated Ca(2 ) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Stoichiometry and arrangement of heteromeric olfactory cyclic nucleotide-gated ion channels

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Conductance and permeation of monovalent cations through depletion-activated Ca2 channels (ICRAC) in Jurkat T cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Tandem linkage of Shaker K channel subunits does not ensure the stoichiometry of expressed channels

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Subunit stoichiometry of a mammalian K channel determined by construction of multimeric cDNAs.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Monomeric and dimeric byproducts are the principal functional elements of higher order P2X1 concatamers

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Subunit arrangement of gamma-aminobutyric acid type A receptors

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336C.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5103002

Generation and Characterization of Fully Human Monoclonal Antibodies Against Human Orai1 for Autoimmune Disease

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27806271

inferred from PubMed ID database lookup

12 December 2020

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Calcium release-activated calcium current in rat mast cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27806271

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BPJ.2016.09.020

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release_m6ihvr7zsrcerifjwttq2hlhje

6 November 2017

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Fatcat

https://api.fatcat.wiki/v0/release/m6ihvr7zsrcerifjwttq2hlhje

mapped directly with Wikidata item

24 November 2022

based on heuristic

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6 November 2017

PubMed publication ID

27806271

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