Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR. (Q42701237)

5 November 2017

title

Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR. (English)

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5 November 2017

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Xiao-Jie Zhang

1

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5 November 2017

Zhe Shi

2

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5 November 2017

Jing-Xi Lyv

3

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5 November 2017

Xuyan He

4

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5 November 2017

Neal A Englert

5

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5 November 2017

Shu-Yun Zhang

6

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5 November 2017

publication date

8 July 2015

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5 November 2017

published in

Toxicological Sciences

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5 November 2017

volume

147

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5 November 2017

issue

2

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5 November 2017

page(s)

436-445

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Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice

5 November 2017

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Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes

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Solution by dilution?--A review on the pollution status of the Yangtze River

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Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in theCYP2B10Gene

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Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

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Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

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Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers

21 January 2018

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Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR.

21 January 2018

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Chemical and biological characterization of air particulate matter 2.5, collected from five cities in China

21 January 2018

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Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism

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21 January 2018

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21 January 2018

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Further insights into the composition, source, and toxicity of PAHs in size-resolved particulate matter in a megacity in China

21 January 2018

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Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression

21 January 2018

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

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Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.

21 January 2018

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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

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Elevated serum liver enzymes in coke oven and by-product workers

21 January 2018

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The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

21 January 2018

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Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver

21 January 2018

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https://api.crossref.org/works/10.1093/TOXSCI/KFV142

Toxicity of polycyclic aromatic hydrocarbons. I. Effect of phenanthrene, pyrene, and their ozonized products on blood chemistry in rats

21 January 2018

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Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

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Human CYP2C8 Is Post-Transcriptionally Regulated by MicroRNAs 103 and 107 in Human Liver

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFV142

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5 November 2017

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