WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function. (Q42676343)

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17 February 2020

title

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function (English)

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17 February 2020

5

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17 February 2020

Barbara Stecca

7

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17 February 2020

author name string

S Pandolfi

1

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17 February 2020

V Montagnani

2

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17 February 2020

J Y Penachioni

3

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17 February 2020

M C Vinci

4

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17 February 2020

L Borgognoni

6

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17 February 2020

language of work or name

English

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publication date

12 November 2012

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17 February 2020

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17 February 2020

volume

32

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17 February 2020

issue

40

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17 February 2020

page(s)

4737-4747

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Hedgehog signaling in animal development: paradigms and principles

17 February 2020

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E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

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Wip1 regulates the generation of new neural cells in the adult olfactory bulb through p53-dependent cell cycle control

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Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

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Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

21 January 2018

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Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine.

21 January 2018

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The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

21 January 2018

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

21 January 2018

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

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Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response

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Over-expression of wild-type p53-induced phosphatase 1 confers poor prognosis of patients with gliomas

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Patched1 regulates hedgehog signaling at the primary cilium

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21 January 2018

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21 January 2018

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21 January 2018

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The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1

21 January 2018

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The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 January 2018

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Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

21 January 2018

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21 January 2018

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

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21 January 2018

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Melanoma biology and new targeted therapy

21 January 2018

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The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin

21 January 2018

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Clinical experience with Hedgehog pathway inhibitors

21 January 2018

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Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).

21 January 2018

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A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2

21 January 2018

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Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.

21 January 2018

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21 January 2018

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In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

21 January 2018

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Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

21 January 2018

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Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma

31 March 2020

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Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.502

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 February 2020

1006878030

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903 AND SRC:MED&resulttype=core&format=json