Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation (Q42576947)

3 November 2017

Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation (English)

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3 November 2017

2

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3 November 2017

6

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3 November 2017

Peter Oatley

3

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Ian Collinson

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Ian Collinson

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8

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Stephen A. Baldwin

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5

object named as

Steve A Baldwin

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3 November 2017

7

Roman Tuma

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3 November 2017

William John Allen

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3 November 2017

Richard Barry Sessions

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4

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3 November 2017

language of work or name

English

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publication date

16 May 2016

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full work available at URL

3 November 2017

http://eprints.whiterose.ac.uk/100010/

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White Rose Research Online

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Creative Commons Attribution

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https://doi.org/10.7554/eLife.15598

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Creative Commons Attribution

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3 November 2017

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3 November 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4907695/fullTextXML

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cites work

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28 May 2018

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28 May 2018

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28 May 2018

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28 May 2018

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28 May 2018

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X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-

28 May 2018

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Different exported proteins in E. coli show differences in the temporal mode of processing in vivo

28 May 2018

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Solvation energy in protein folding and binding

28 May 2018

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SecA protein hydrolyzes ATP and is an essential component of the protein translocation ATPase of Escherichia coli

28 May 2018

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The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane

28 May 2018

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The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.

28 May 2018

1 reference

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Conformational and membrane-binding properties of a signal sequence are largely unaltered by its adjacent mature region

28 May 2018

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Reconstitution of a protein translocation system containing purified SecY, SecE, and SecA from Escherichia coli

28 May 2018

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What drives the translocation of proteins?

28 May 2018

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A protein of the endoplasmic reticulum involved early in polypeptide translocation

28 May 2018

1 reference

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SecA supports a constant rate of preprotein translocation.

28 May 2018

1 reference

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Toward a detailed description of the pathways of allosteric communication in the GroEL chaperonin through atomistic simulation.

28 May 2018

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Charged amino acids in a preprotein inhibit SecA-dependent protein translocation.

16 August 2018

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A role for the two-helix finger of the SecA ATPase in protein translocation.

16 August 2018

1 reference

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Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907695

Allosteric regulation of SecA: magnesium-mediated control of conformation and activity.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907695

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4907695

GROMACS: A message-passing parallel molecular dynamics implementation

16 August 2018

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Crossref

https://api.crossref.org/works/10.7554/ELIFE.15598

Exact stochastic simulation of coupled chemical reactions

21 January 2018

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Crossref

https://api.crossref.org/works/10.7554/ELIFE.15598

A molecular switch in SecA protein couples ATP hydrolysis to protein translocation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554/ELIFE.15598

Short hydrophobic segments in the mature domain of ProOmpA determine its stepwise movement during translocation across the cytoplasmic membrane of Escherichia coli

21 January 2018

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12 December 2020

United Atom Lipid Parameters for Combination with the Optimized Potentials for Liquid Simulations All-Atom Force Field

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12 December 2020

A temperature-sensitive mutant of E. coli exhibiting slow processing of exported proteins

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12 December 2020

Site-directed mutations in motif VI of Escherichia coli DNA helicase II result in multiple biochemical defects: evidence for the involvement of motif VI in the coupling of ATPase and DNA binding activities via conformational changes

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12 December 2020

Secondary structure formation of a transmembrane segment in Kv channels

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12 December 2020

Observation of multiple myosin subfragment 1-ADP-fluoroberyllate complexes by 19F NMR spectroscopy

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12 December 2020

Identifiers

DOI

10.7554/ELIFE.15598

1 reference

Dimensions Publication ID

3 November 2017

0 references

0 references

1 reference

3 November 2017

PubMed publication ID

27183269

1 reference