Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. (Q42555356)

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17 October 2019

title

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis (English)

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17 October 2019

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1

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Seamus Martin

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E H Schuchman

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17 October 2019

author name string

L A Peña

2

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A Haimovitz-Friedman

3

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D Green

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M McLoughlin

6

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C Cordon-Cardo

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Z Fuks

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R Kolesnick

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17 October 2019

language of work or name

English

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publication date

1 July 1996

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17 October 2019

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volume

86

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issue

2

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17 October 2019

page(s)

189-199

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Radiation-induced apoptosis: its role in a MADCaT (mitosis-apoptosis-differentiation-calcium toxicity) scheme of cytotoxicity mechanisms

17 October 2019

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Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

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FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

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Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

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Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

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Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

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Sphingomyelin and derivatives as cellular signals

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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

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Niemann-Pick type B disease. Identification of a single codon deletion in the acid sphingomyelinase gene and genotype/phenotype correlations in type A and B patients

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Niemann-Pick disease: a frequent missense mutation in the acid sphingomyelinase gene of Ashkenazi Jewish type A and B patients

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Compartmentalized Production of Ceramide at the Cell Surface

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Cancer therapy and p53.

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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Purification and characterization of neutral and acid sphingomyelinases from rat brain.

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Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta

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Quantitation of free sphingosine in liver by high-performance liquid chromatography

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PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

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Fluorescence-Based Selection of Retrovirally Transduced Cells in the Absence of a Marker Gene: Direct Selection of Transduced Type B Niemann-Pick Disease Cells and Evidence for Bystander Correction

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7 January 2021

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Identifiers

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17 October 2019

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