The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. (Q42536961)

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scientific article published on January 1999

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English	The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development.	scientific article published on January 1999

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8 December 2019

The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development (English)

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8 December 2019

Caenorhabditis elegans

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H. Robert Horvitz

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H R Horvitz

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8 December 2019

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Y Jin

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8 December 2019

E Jorgensen

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8 December 2019

E Hartwieg

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8 December 2019

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1 January 1999

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8 December 2019

Journal of Neuroscience

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8 December 2019

19

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8 December 2019

2

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8 December 2019

539-548

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8 December 2019

The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD.

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The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins

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Calcium and chemotropic turning of nerve growth cones

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Drosophila GABAergic Systems: Sequence and Expression of Glutamic Acid Decarboxylase

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A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region

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Dual function of the intron of the rat insulin I gene in regulation of gene expression

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Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67

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A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

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Translational attenuation mediated by an mRNA intron

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12 December 2020

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Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons.

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The C. elegans unc-104 4 gene encodes a putative kinesin heavy chain-like protein

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Regulation of gamma-aminobutyric acid synthesis in the brain

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Pathway selection by embryonic chick motoneurons in an experimentally altered environment

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Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures

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The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen

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Drosophila GABAergic systems. II. Mutational analysis of chromosomal segment 64AB, a region containing the glutamic acid decarboxylase gene.

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GABA-induced motility of spinal neuroblasts develops along a ventrodorsal gradient and can be mimicked by agonists of GABAA and GABAB receptors

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12 December 2020

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Two genes encode distinct glutamate decarboxylases

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The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle.

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Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans.

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Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65

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12 December 2020

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Localization of mRNAs encoding two forms of glutamic acid decarboxylase in the rat hippocampal formation.

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The regulation of gene expression in transformed maize aleurone and endosperm protoplasts. Analysis of promoter activity, intron enhancement, and mRNA untranslated regions on expression.

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Neurotransmitter regulation of neuronal outgrowth, plasticity and survival

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Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha

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12 December 2020

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Posttranscriptional regulation of thymidylate synthase gene expression

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Genes necessary for directed axonal elongation or fasciculation in C. elegans

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The role of GABA during development of the outer retina in the rabbit

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The Structure of the Nervous System of the Nematode Caenorhabditis elegans

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The GABAergic nervous system of Caenorhabditis elegans

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Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient

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1 reference

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12 December 2020

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1 reference

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12 December 2020

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1 reference

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1 reference

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1 reference

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1 reference

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inferred from PubMed ID database lookup

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1 reference

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1 reference

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12 December 2020

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1 reference

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Identifiers

10.1523/JNEUROSCI.19-02-00539.1999

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9880574 AND SRC:MED&resulttype=core&format=json

8 December 2019

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9880574 AND SRC:MED&resulttype=core&format=json

8 December 2019

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9880574 AND SRC:MED&resulttype=core&format=json

8 December 2019

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