Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression (Q42484543)

1 November 2017

title

Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression (English)

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1 November 2017

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Muraoka-Cook RS

1

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1 November 2017

Shin I

2

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1 November 2017

Yi JY

3

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1 November 2017

Easterly E

4

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1 November 2017

Barcellos-Hoff MH

5

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1 November 2017

Yingling JM

6

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1 November 2017

Zent R

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1 November 2017

Arteaga CL

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1 November 2017

language of work or name

English

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publication date

26 September 2005

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1 November 2017

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1 November 2017

volume

25

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1 November 2017

issue

24

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1 November 2017

page(s)

3408-3423

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Delayed mammary gland involution in MMTV-AKT1 transgenic mice

1 November 2017

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Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression

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Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases.

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FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors.

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Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

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E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

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Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

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Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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Autocrine transforming growth factor-beta signaling mediates Smad-independent motility in human cancer cells.

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Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation

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Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation

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Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis

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Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

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Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells

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Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor.

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Transforming growth factor-beta 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities

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Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

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Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

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Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population

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7 January 2021

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

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7 January 2021

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

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TGF-beta signal transduction

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TGFbeta signaling in growth control, cancer, and heritable disorders

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Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

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ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

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Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function

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Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors

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Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition

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7 January 2021

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

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7 January 2021

PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

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7 January 2021

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

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7 January 2021

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

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7 January 2021

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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7 January 2021

Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

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7 January 2021

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

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7 January 2021

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

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7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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7 January 2021

TGF-beta signaling: positive and negative effects on tumorigenesis

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208964

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Dimensions Publication ID

1 November 2017

1047636734

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