Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k). (Q42474271)

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scientific article published on 11 February 2005

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English	Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).	scientific article published on 11 February 2005

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8 January 2020

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k) (English)

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8 January 2020

Dylan R. Edwards

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8 January 2020

Elisabetta Renzoni

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8 January 2020

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Christopher P Denton

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8 January 2020

Gisela E Lindahl

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8 January 2020

Korsa Khan

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8 January 2020

Xu Shiwen

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8 January 2020

Voon H Ong

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8 January 2020

Nicholas J Gaspar

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8 January 2020

Konstantinos Lazaridis

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8 January 2020

Andrew Leask

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8 January 2020

Mark Eastwood

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8 January 2020

Patricia Leoni

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8 January 2020

George Bou Gharios

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8 January 2020

David J Abraham

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8 January 2020

Carol M Black

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8 January 2020

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11 February 2005

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8 January 2020

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Journal of Biological Chemistry

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8 January 2020

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16053-16065

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8 January 2020

Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis

1 reference

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Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma

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Apoptosis and myofibroblasts in the pathogenesis of systemic sclerosis

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Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1.

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21 January 2018

Smad3 as a mediator of the fibrotic response

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Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts

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21 January 2018

Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.

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Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.

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Identification of multiple, differentially expressed messenger RNAs in dermal fibroblasts from patients with systemic sclerosis

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Deficient Smad7 expression: a putative molecular defect in scleroderma

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21 January 2018

Systemic and cell type-specific gene expression patterns in scleroderma skin

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A potential role for protease nexin 1 overexpression in the pathogenesis of scleroderma

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21 January 2018

Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts

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21 January 2018

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

1 reference

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21 January 2018

Transgenic analysis of scleroderma: understanding key pathogenic events in vivo

1 reference

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21 January 2018

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

1 reference

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21 January 2018

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

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21 January 2018

The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3.

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis

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21 January 2018

Myofibroblasts and mechano-regulation of connective tissue remodelling

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Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis

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Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring

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Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds

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Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts

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Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

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Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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21 January 2018

An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma

1 reference

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21 January 2018

The myofibroblast in wound healing and fibrocontractive diseases

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21 January 2018

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

1 reference

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21 January 2018

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

1 reference

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21 January 2018

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

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10.1074/JBC.M413134200

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15708853 AND SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15708853 AND SRC:MED&resulttype=core&format=json

8 January 2020

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