Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation (Q42435698)

31 October 2017

title

Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation (English)

1 reference

31 October 2017

Hsueh-Meei Huang

1

1 reference

31 October 2017

Hui Zhang

series ordinal

2

1 reference

31 October 2017

Hui Xu

series ordinal

3

1 reference

31 October 2017

Gary E Gibson

series ordinal

4

1 reference

31 October 2017

publication date

1 January 2003

1 reference

Biochimica et Biophysica Acta

31 October 2017

published in

1 reference

31 October 2017

volume

1637

1 reference

31 October 2017

issue

1

1 reference

31 October 2017

page(s)

119-126

1 reference

Mitochondrial dysfunction in neurodegenerative disorders

31 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondrial dysfunction in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Role of mitochondria in the etiology and pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Presenilins, the Endoplasmic Reticulum, and Neuronal Apoptosis in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Internal Ca2 mobilization is altered in fibroblasts from patients with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Abnormalities in Alzheimer’s Disease Fibroblasts Bearing the APP670/671 Mutation

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondria and Na /Ca2 exchange buffer glutamate-induced calcium loads in cultured cortical neurons

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondrial dysfunction is a primary event in glutamate neurotoxicity

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondria and neuronal survival

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

The cellular production of hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Keilin's Respiratory Chain Concept and Its Chemiosmotic Consequences

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

'Cross-talk' between redox- and ATP-driven H pumps

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Intracellular fluorescent probe concentrations by confocal microscopy

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Caspase independent/dependent regulation of K( ), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Assessment of membrane potentials of mitochondrial populations in living cells

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondrial control of apoptosis: the role of cytochrome c

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Cytochrome C is released from mitochondria into the cytosol after cerebral anoxia or ischemia

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

A mitochondrial perspective on cell death

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin B-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2 ions

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Biochemical approaches to the study of cytosolic calcium regulation in nerve endings

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Regulation of mitochondrial metabolism by ER Ca2 release: an intimate connection

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondria and calcium: from cell signalling to cell death

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Neuronal excitotoxicity: the role of mitochondria

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Bcl-2 decreases the free Ca2 concentration within the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

The Ca2 concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Inhibition of acetylcholine synthesis and of carbohydrate utilization by maple-syrup-urine disease metabolites

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Inhibition by the branched-chain 2-oxo acids of the 2-oxoglutarate dehydrogenase complex in developing rat and human brain

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Kinetic properties of the partially purified pyruvate dehydrogenase complex of ox brain

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Normal glutamate metabolism in Alzheimer's disease fibroblasts deficient in alpha-ketoglutarate dehydrogenase complex activity

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondria and cell death. Mechanistic aspects and methodological issues

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Cell and molecular neurobiology of presenilins: A role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain?

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury?

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Interaction of thioredoxins with target proteins: role of particular structural elements and electrostatic properties of thioredoxins in their interplay with 2-oxoacid dehydrogenase complexes

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Mitochondria recycle Ca(2 ) to the endoplasmic reticulum and prevent the depletion of neighboring endoplasmic reticulum regions

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Requirement of glycolytic and mitochondrial energy supply for loading of Ca(2 ) stores and InsP(3)-mediated Ca(2 ) signaling in rat hippocampus astrocytes

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2 responses

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

On the role of the calcium transport cycle in heart and other mammalian mitochondria

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(02)00222-3

7 January 2021

10.1016/S0925-4439(02)00222-3

Identifiers

DOI

1 reference

31 October 2017

1 reference