Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa. (Q42408709)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16723580 AND SRC:MED&resulttype=core&format=json

28 January 2020

title

Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa (English)

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28 January 2020

main subject

Pseudomonas aeruginosa

object named as

Pseudomonas aeruginosa

1 reference

inferred from title

author

Charles Kendall Stover

12

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28 January 2020

author name string

Khisimuzi E Mdluli

1

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28 January 2020

Pamela R Witte

2

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28 January 2020

Toni Kline

3

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28 January 2020

Adam W Barb

4

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28 January 2020

Alice L Erwin

5

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28 January 2020

Bryce E Mansfield

6

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28 January 2020

Amanda L McClerren

7

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28 January 2020

Michael C Pirrung

8

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28 January 2020

L Nathan Tumey

9

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28 January 2020

Paul Warrener

10

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28 January 2020

Christian R H Raetz

11

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28 January 2020

language of work or name

English

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publication date

1 June 2006

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Antimicrobial Agents and Chemotherapy

28 January 2020

published in

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28 January 2020

volume

50

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28 January 2020

issue

6

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28 January 2020

page(s)

2178-2184

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A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin

28 January 2020

cites work

1 reference

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Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.

28 May 2018

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Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway

28 May 2018

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Comprehensive transposon mutant library of Pseudomonas aeruginosa

28 May 2018

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Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

28 May 2018

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High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties

28 May 2018

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Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.

28 May 2018

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Antibacterial activities and characterization of novel inhibitors of LpxC.

28 May 2018

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Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria

28 May 2018

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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

28 May 2018

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UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme

28 May 2018

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Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems

28 May 2018

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Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway

28 May 2018

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Luciferase in vivo expression technology: use of recombinant mycobacterial reporter strains to evaluate antimycobacterial activity in mice.

28 May 2018

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The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase

28 May 2018

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Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin

28 May 2018

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An improved system for gene replacement and xylE fusion analysis in Pseudomonas aeruginosa

28 May 2018

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Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

28 May 2018

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Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant

28 May 2018

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Penetration of beta-lactam antibiotics into their target enzymes in Pseudomonas aeruginosa: comparison of a highly sensitive mutant with its parent strain

28 May 2018

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Regulation of the araC gene of Escherichia coli: catabolite repression, autoregulation, and effect on araBAD expression

28 May 2018

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Development of broad-host-range vectors and gene banks: self-cloning of the Pseudomonas aeruginosa PAO chromosome

28 May 2018

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28 May 2018

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28 May 2018

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Products of three accessory genes, pilB, pilC, and pilD, are required for biogenesis of Pseudomonas aeruginosa pili

28 May 2018

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28 May 2018

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28 May 2018

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Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups

16 August 2018

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Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site

16 August 2018

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Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesis.

16 August 2018

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Genetic recombination in Pseudomonas aeruginosa

16 August 2018

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PubMed

12 December 2020

Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis

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PubMed

12 December 2020

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12 December 2020

Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs

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PubMed

12 December 2020

Identifiers

DOI

10.1128/AAC.00140-06

1 reference

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28 January 2020

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28 January 2020

PubMed publication ID

16723580

1 reference