Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR. (Q42383178)

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scientific article published on 30 August 2016

Language	Label	Description	Also known as
English	Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.	scientific article published on 30 August 2016

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR. (English)

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

protein ubiquitination

1 reference

based on heuristic

inferred from title

sex-determination system

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based on heuristic

inferred from title

author name string

Joseph D Racca

1

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Yen-Shan Chen

2

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Yanwu Yang

3

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Nelson B Phillips

4

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Europe PubMed Central

PMC publication ID

28 October 2017

Michael A Weiss

5

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Europe PubMed Central

PMC publication ID

28 October 2017

language of work or name

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publication date

30 August 2016

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Europe PubMed Central

PMC publication ID

28 October 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

28 October 2017

291

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Europe PubMed Central

PMC publication ID

28 October 2017

42

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

22173-22195

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5063998/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

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Mammalian proteasome subtypes: Their diversity in structure and function

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Structural and functional conservation of fungal MatA and human SRY sex-determining proteins

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Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box.

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Regulating the 20S proteasome ubiquitin-independent degradation pathway

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Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination

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Advantages of proteins being disordered.

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Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold

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Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty

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The molecular and cellular basis of gonadal sex reversal in mice and humans

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Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness

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Robustness, evolvability, and the logic of genetic regulation

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The SOX gene family: function and regulation in testis determination and male fertility maintenance

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How to evolve new vertebrate sex determining genes

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28 May 2018

Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.

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Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex.

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Protein targeting and degradation are coupled for elimination of mislocalized proteins

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Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

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Mutational robustness can facilitate adaptation

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28 May 2018

SRY: A transcriptional activator of mammalian testis determination

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The incoherent feedforward loop can provide fold-change detection in gene regulation

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The emerging complexity of protein ubiquitination

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28 May 2018

A novel SRY missense mutation affecting nuclear import in a 46,XY female patient with bilateral gonadoblastoma.

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Determination of enriched histone modifications in non-genic portions of the human genome

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Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice

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28 May 2018

Sex determination and SRY: down to a wink and a nudge?

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28 May 2018

Boys, girls and shuttling of SRY and SOX9.

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28 May 2018

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

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28 May 2018

Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans

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28 May 2018

20S proteasomes and protein degradation "by default".

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28 May 2018

SRY-directed DNA bending and human sex reversal: reassessment of a clinical mutation uncovers a global coupling between the HMG box and its tail

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28 May 2018

Stochastic models for regulatory networks of the genetic toggle switch

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28 May 2018

Isolation of the lac repressor

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28 May 2018

Sox9 in testis determination

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28 May 2018

Minireview: transcriptional regulation of gonadal development and differentiation.

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28 May 2018

Histones and histone modifications

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28 May 2018

The ins and outs of transcriptional control: nucleocytoplasmic shuttling in development and disease

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Turning on the male--SRY, SOX9 and sex determination in mammals.

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28 May 2018

Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.

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28 May 2018

Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles

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28 May 2018

Familial mutation in the testis-determining gene SRY shared by an XY female and her normal father

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Evolution of the testis-determining gene--the rise and fall of SRY.

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28 May 2018

Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation

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28 May 2018

The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.

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Mechanisms underlying ubiquitination

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Intracellular proteolysis

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Sry requires a CAG repeat domain for male sex determination in Mus musculus

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28 May 2018

Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway

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28 May 2018

Phosphorylation of an N-terminal motif enhances DNA-binding activity of the human SRY protein.

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28 May 2018

A novel missense mutation (S18N) in the 5' non-HMG box region of the SRY gene in a patient with partial gonadal dysgenesis and his normal male relatives

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28 May 2018

Regulation of Sexual Dimorphism in Mammals

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28 May 2018

The SRY Cantilever Motif Discriminates Between Sequence- and Structure-Specific DNA Recognition: Alanine Mutagenesis of an HMG Box

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28 May 2018

Mutational analysis of the SOX9 gene in campomelic dysplasia and autosomal sex reversal: lack of genotype/phenotype correlations

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28 May 2018

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28 May 2018

Alignment of 700 globin sequences: extent of amino acid substitution and its correlation with variation in volume

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28 May 2018

Ancestry and diversity of the HMG box superfamily

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28 May 2018

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity

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28 May 2018

Homeodomain-DNA recognition

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28 May 2018

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

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28 May 2018

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

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28 May 2018

Molecular basis of mammalian sexual determination: activation of Müllerian inhibiting substance gene expression by SRY.

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28 May 2018

Normal onset, but prolonged expression, of Sry gene in the B6.YDOM sex-reversed mouse gonad

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28 May 2018

Nuclear localization of the testis determining gene product SRY.

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28 May 2018

Sry is a transcriptional activator

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28 May 2018

Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex

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28 May 2018

Structural basis for DNA bending by the architectural transcription factor LEF-1

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28 May 2018

NMR spectroscopic analysis of the DNA conformation induced by the human testis determining factor SRY.

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28 May 2018

Reaction of 20S proteasome: shift of SDS-dependent activation profile by divalent cations

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28 May 2018

lambda Repressor and cro--components of an efficient molecular switch

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28 May 2018

Genetics, chance, and morphogenesis.

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28 May 2018

Molecular determinants of protein half-lives in eukaryotic cells

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28 May 2018

Molecular events regulating messenger RNA stability in eukaryotes

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28 May 2018

Male development of chromosomally female mice transgenic for Sry.

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28 May 2018

DNA Binding Activity of Recombinant SRY from Normal Males and XY Females

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28 May 2018

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

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28 May 2018

The primary sex determination signal of Drosophila acts at the level of transcription

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28 May 2018

A familial mutation in the testis-determining gene SRY shared by both sexes

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28 May 2018

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

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28 May 2018

Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues

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28 May 2018

Association of hsa-miR‑145 overexpression in human testicular cells with male infertility.

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16 August 2018

SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending

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16 August 2018

Sry-directed sex reversal in transgenic mice is robust with respect to enhanced DNA bending: comparison of human and murine HMG boxes

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16 August 2018

Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli

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16 August 2018

Novel mutations affecting SRY DNA-binding activity: the HMG box N65H associated with 46,XY pure gonadal dysgenesis and the familial non-HMG box R30I associated with variable phenotypes.

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16 August 2018

Human sex reversal due to impaired nuclear localization of SRY. A clinical correlation.

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16 August 2018

Does one gene determine whether a C57BL/6J-Y(POS) mouse will develop as a female or as an hermaphrodite?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063998

16 August 2018

Independent observation of SRY mutation I90M in a patient with complete gonadal dysgenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063998

16 August 2018

Sex-determining genes on mouse autosomes identified by linkage analysis of C57BL/6J-YPOS sex reversal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063998

16 August 2018

Gene regulation at the right operator (OR) of bacteriophage lambda. II. OR1, OR2, and OR3: their roles in mediating the effects of repressor and cro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5063998

16 August 2018

In retrospect: Twenty-five years of thesex-determining gene

1 reference

https://api.crossref.org/works/10.1074/JBC.M116.741959

21 January 2018

A novel mutation localized in the 3' non-HMG box region of the SRY gene in 46,XY gonadal dysgenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel sex-determining region on Y (SRY) missense mutation identified in a 46,XY female and also in the father

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inherited sex reversal in mice: identification of a new primary sex-determining gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HMGs everywhere

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different conformations of double-stranded nucleic acid in solution as revealed by circular dichroism

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2 -induced alteration in the unfolding behavior of alpha-lactalbumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The energetics of HMG box interactions with DNA: thermodynamics of the DNA binding of the HMG box from mouse sox-5

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS

1 reference

https://pubmed.ncbi.nlm.nih.gov/27576690

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M116.741959

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

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