The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding. (Q42355233)

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scientific article published on 8 December 2016

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English	The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.	scientific article published on 8 December 2016

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29 March 2020

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding (English)

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29 March 2020

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29 March 2020

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29 March 2020

Thomas J.D. Jørgensen

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29 March 2020

Stephen G. Young

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André Bensadouen

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André Bensadouen

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Gunilla Olivecrona

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Gunilla Olivecrona

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Oleg Kovrov

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Kristian Kølby Kristensen

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Mikael Larsson

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29 March 2020

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29 March 2020

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1 reference

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GPIHBP1 and Plasma Triglyceride Metabolism

1 reference

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Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease

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29 May 2018

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

1 reference

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29 May 2018

Role of lipoprotein lipase in lipid metabolism

1 reference

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29 May 2018

Regulation of lipid metabolism by angiopoietin-like proteins

1 reference

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29 May 2018

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

1 reference

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Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

1 reference

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29 May 2018

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.

1 reference

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29 May 2018

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

1 reference

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29 May 2018

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

1 reference

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29 May 2018

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.

1 reference

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An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

1 reference

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29 May 2018

GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding.

1 reference

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29 May 2018

Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain

1 reference

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29 May 2018

The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

Comparative analyses of lipoprotein lipase, hepatic lipase, and endothelial lipase, and their binding properties with known inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

Fatty Acids Bind Tightly to the N-terminal Domain of Angiopoietin-like Protein 4 and Modulate Its Interaction with Lipoprotein Lipase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking

1 reference

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The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk

1 reference

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29 May 2018

GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries

1 reference

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Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia

1 reference

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Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample

1 reference

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29 May 2018

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase

1 reference

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29 May 2018

Genetic variation in ANGPTL4 provides insights into protein processing and function

1 reference

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29 May 2018

A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

29 May 2018

The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms

1 reference

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GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins

1 reference

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Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

1 reference

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Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

1 reference

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Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons

1 reference

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Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue

1 reference

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Protein unfolding in the cell

1 reference

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29 May 2018

Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148603

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Quality control in the endoplasmic reticulum

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Protein secondary structure prediction based on position-specific scoring matrices

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Purification and characterization of human lipoprotein lipase and hepatic triglyceride lipase. Reactivity with monoclonal antibodies to hepatic triglyceride lipase.

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Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).

1 reference

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Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4.

1 reference

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Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4

1 reference

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12 December 2020

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Novel mutations in the GPIHBP1 gene identified in 2 patients with recurrent acute pancreatitis

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Positional dependence of the effects of negatively charged Glu side chains on the stability of two-stranded α-helical coiled-coils

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Negatively-charged helices in the gas phase

1 reference

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12 December 2020

based on heuristic

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Binding of deoxycholate to lipoprotein lipase

1 reference

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12 December 2020

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Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27929370

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.7554/ELIFE.20958

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29 March 2020

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Europe PubMed Central

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29 March 2020

PubMed publication ID

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Europe PubMed Central

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29 March 2020

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