Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells (Q42320736)

26 October 2017

Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells (English)

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26 October 2017

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2

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9 June 2020

author name string

Chun-Ting Cheng

1

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9 June 2020

Ching Ouyang

3

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9 June 2020

Chien-Feng Li

4

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9 June 2020

Yiyin Chung

5

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9 June 2020

David C Chan

6

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9 June 2020

Hsing-Jien Kung

7

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9 June 2020

David K Ann

8

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9 June 2020

language of work or name

English

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publication date

30 June 2016

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26 October 2017

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9 June 2020

volume

76

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9 June 2020

issue

17

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9 June 2020

page(s)

5006-5018

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Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype

9 June 2020

cites work

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Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress

26 October 2017

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Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

26 October 2017

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Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors

26 October 2017

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AMACR amplification and overexpression in primary imatinib-naïve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis

26 October 2017

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KAP1 promotes proliferation and metastatic progression of breast cancer cells

26 October 2017

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Dynamic involvement of ATG5 in cellular stress responses.

26 October 2017

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KAPtain in charge of multiple missions: Emerging roles of KAP1

26 October 2017

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Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

26 October 2017

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An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress

26 October 2017

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Shaping the dynamic mitochondrial network

26 October 2017

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Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation

26 October 2017

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Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells.

26 October 2017

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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

26 October 2017

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Role of mitofusin 2 (Mfn2) in controlling cellular proliferation

26 October 2017

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Glutamine and cancer: cell biology, physiology, and clinical opportunities

26 October 2017

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Anti-tumor effects of Mfn2 in gastric cancer

26 October 2017

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Drilling into big cancer-genome data

26 October 2017

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Mitochondrial dynamics regulates migration and invasion of breast cancer cells

26 October 2017

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Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

26 October 2017

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Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response

26 October 2017

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Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

26 October 2017

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Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia

26 October 2017

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Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism.

26 October 2017

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Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

26 October 2017

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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.

26 October 2017

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Regulation of cancer cell metabolism

26 October 2017

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Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.

26 October 2017

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26 October 2017

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

26 October 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

26 October 2017

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Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

26 October 2017

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26 October 2017

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26 October 2017

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26 October 2017

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Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation

26 October 2017

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Pooling breast cancer datasets has a synergetic effect on classification performance and improves signature stability

26 October 2017

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Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.

26 October 2017

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Adenovirus-expressed human hyperplasia suppressor gene induces apoptosis in cancer cells

26 October 2017

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Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5316485

Reactive oxygen species: a breath of life or death?

26 October 2017

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KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions

26 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5316485

Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells

26 October 2017

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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

26 October 2017

1 reference

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Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

26 October 2017

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

26 October 2017

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A gene-expression signature as a predictor of survival in breast cancer

26 October 2017

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Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?

26 October 2017

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Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.

26 October 2017

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10.1158/0008-5472.CAN-15-2921

17 August 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27364555 AND SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27364555 AND SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

27364555

1 reference