IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination. (Q42277634)

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scientific article published on 6 August 2013

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English	IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination.	scientific article published on 6 August 2013

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23933364 AND SRC:MED&resulttype=core&format=json

7 March 2020

IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23933364 AND SRC:MED&resulttype=core&format=json

7 March 2020

Danushka Wijesundara

1

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7 March 2020

Ronald J Jackson

2

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7 March 2020

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7 March 2020

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Charani Ranasinghe

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7 March 2020

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6 August 2013

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7 March 2020

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7 March 2020

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7 March 2020

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7 March 2020

4548-4555

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7 March 2020

Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel

1 reference

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Superior control of HIV-1 replication by CD8 T cells is reflected by their avidity, polyfunctionality, and clonal turnover

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Expression and function of CD8 in a murine T cell hybridoma

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Functional avidity maturation of CD8( ) T cells without selection of higher affinity TCR

1 reference

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High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL.

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Multifunctional human immunodeficiency virus (HIV) gag-specific CD8 T-cell responses in rectal mucosa and peripheral blood mononuclear cells during chronic HIV type 1 infection.

1 reference

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Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

1 reference

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7 January 2021

A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L

1 reference

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7 January 2021

Unique IL-13Rα2-based HIV-1 vaccine strategy to enhance mucosal immunity, CD8( ) T-cell avidity and protective immunity.

1 reference

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7 January 2021

Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8 T cells with regime-dependent cytokine/granzyme B profiles

1 reference

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7 January 2021

Reduced interleukin-4 receptor α expression on CD8 T cells correlates with higher quality anti-viral immunity

1 reference

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7 January 2021

Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8( ) CTL avidity

1 reference

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7 January 2021

Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1.

1 reference

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7 January 2021

Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8( ) T cell responses

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7 January 2021

Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation

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7 January 2021

Progressive differentiation and commitment of CD8 T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4.

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7 January 2021

Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8 T cells

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7 January 2021

A novel functional CTL avidity/activity compartmentalization to the site of mucosal immunization contributes to protection of macaques against simian/human immunodeficiency viral depletion of mucosal CD4 T cells

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Generation of functionally active HIV-1 specific CD8 CTL in intestinal mucosa following mucosal, systemic or mixed prime-boost immunization

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Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques

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Impact of vaccine-induced mucosal high-avidity CD8 CTLs in delay of AIDS viral dissemination from mucosa

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7 January 2021

Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3.

1 reference

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7 January 2021

Lack of IL‐7 and IL‐15 signaling affects interferon‐γ production by, more than survival of, small intestinal intraepithelial memory CD8 T cells

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Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production

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Contribution of T cell receptor affinity to overall avidity for virus-specific CD8 T cell responses

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Elevation of IgE in HIV-infected children and its correlation with the progression of disease

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