aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface. (Q42205315)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24700503 AND SRC:MED&resulttype=core&format=json

12 March 2020

title

aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface (English)

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12 March 2020

8

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12 March 2020

Tomonori Hirose

2

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12 March 2020

author name string

Daisuke Satoh

1

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12 March 2020

Yutaka Harita

3

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12 March 2020

Chikara Daimon

4

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12 March 2020

Tomonori Harada

5

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12 March 2020

Hidetake Kurihara

6

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12 March 2020

Akio Yamashita

7

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12 March 2020

language of work or name

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3 April 2014

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24700503 AND SRC:MED&resulttype=core&format=json

The Journal of Biochemistry

12 March 2020

number of pages

14

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based on heuristic

inferred from page(s)

published in

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12 March 2020

volume

156

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12 March 2020

issue

2

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12 March 2020

page(s)

115-128

1 reference

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

12 March 2020

copyright license

start time

20 December 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4112437/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis

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aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation

26 October 2017

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mVps34 deletion in podocytes causes glomerulosclerosis by disrupting intracellular vesicle trafficking

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CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

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Numb controls E-cadherin endocytosis through p120 catenin with aPKC.

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KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

26 October 2017

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CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes

26 October 2017

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Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis

26 October 2017

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Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

26 October 2017

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Nephrin-signature molecule of the glomerular podocyte?

26 October 2017

1 reference

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An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation

26 October 2017

1 reference

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Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis

26 October 2017

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The exocyst complex in polarized exocytosis

26 October 2017

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RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC

26 October 2017

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An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms

26 October 2017

1 reference

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Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis

26 October 2017

1 reference

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Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity

26 October 2017

1 reference

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Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.

26 October 2017

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beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity

26 October 2017

1 reference

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Clinical impact of research on the podocyte slit diaphragm

26 October 2017

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26 October 2017

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Hereditary proteinuria syndromes and mechanisms of proteinuria

26 October 2017

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The PAR-aPKC system: lessons in polarity

26 October 2017

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Glucose transporter 4: cycling, compartments and controversies

26 October 2017

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Rab13 mediates the continuous endocytic recycling of occludin to the cell surface

26 October 2017

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Plasma membrane targeting of podocin through the classical exocytic pathway: effect of NPHS2 mutations

26 October 2017

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Expression of nephrin, podocin, alpha-actinin, and WT1 in children with nephrotic syndrome

26 October 2017

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Expression of podocyte-associated molecules in acquired human kidney diseases

26 October 2017

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Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin

26 October 2017

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26 October 2017

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Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome

26 October 2017

1 reference

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PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes

26 October 2017

1 reference

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Defective nephrin trafficking caused by missense mutations in the NPHS1 gene: insight into the mechanisms of congenital nephrotic syndrome

26 October 2017

1 reference

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Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Nephrin in experimental glomerular disease.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

A direct role for Met endocytosis in tumorigenesis.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Insulin-stimulated plasma membrane association and activation of Akt2, aPKC zeta and aPKC lambda in high fat fed rodent skeletal muscle.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Nephrin and podocin expression around the onset of puromycin aminonucleoside nephrosis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Key molecular events in puromycin aminonucleoside nephrosis rats

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Expression of nephrin in acquired human glomerular disease.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112437

Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24700503

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/JB/MVU022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24700503 AND SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24700503 AND SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

24700503

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24700503 AND SRC:MED&resulttype=core&format=json