Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes (Q42180308)

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4 January 2020

title

Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes (English)

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4 January 2020

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3

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4 January 2020

author name string

Souzan B Yanni

1

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4 January 2020

Pieter P Annaert

2

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4 January 2020

Arlene Bridges

4

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4 January 2020

Yan Gao

5

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4 January 2020

Daniel K Benjamin

6

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4 January 2020

Dhiren R Thakker

7

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4 January 2020

publication date

24 March 2008

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Drug Metabolism and Disposition

4 January 2020

published in

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4 January 2020

volume

36

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4 January 2020

issue

6

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4 January 2020

page(s)

1119-1125

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Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3).

4 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Pharmacokinetic/pharmacodynamic profile of voriconazole

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Newer systemic antifungal agents : pharmacokinetics, safety and efficacy

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Pharmacokinetics and safety of intravenous voriconazole in children after single- or multiple-dose administration

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

No clinically significant pharmacokinetic interactions between voriconazole and indinavir in healthy volunteers

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

No clinically significant effect of erythromycin or azithromycin on the pharmacokinetics of voriconazole in healthy male volunteers

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Voriconazole, a novel wide‐spectrum triazole: oral pharmacokinetics and safety

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

The pharmacokinetics and safety of intravenous voriconazole – a novel wide‐spectrum antifungal agent

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Pharmacokinetics and safety of voriconazole following intravenous- to oral-dose escalation regimens

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Structural and catalytic properties of the mammalian flavin-containing monooxygenase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Developmental expression of human hepatic CYP2C9 and CYP2C19.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Identification of the Cytochrome P450 Enzymes Involved in theN-Oxidation of Voriconazole

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Safety and pharmacokinetics of oral voriconazole in patients at risk of fungal infection: a dose escalation study

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Potent cytochrome P450 2C19 genotype–related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737669

Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18362161

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Early use of antifungal therapy in high-risk patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18362161

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Flavin-containing monooxygenase-mediated metabolism of N-deacetyl ketoconazole by rat hepatic microsomes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18362161

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/DMD.107.019646

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18362161 AND SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18362161 AND SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

18362161

1 reference