Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide (Q42146193)

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4 February 2020

title

Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide (English)

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4 February 2020

1

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4 February 2020

author name string

J Patrick Loria

series ordinal

2

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4 February 2020

Andrew D Miranker

series ordinal

3

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4 February 2020

language of work or name

English

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publication date

30 July 2009

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Journal of Molecular Biology

4 February 2020

published in

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4 February 2020

volume

393

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4 February 2020

issue

2

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4 February 2020

page(s)

383-396

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The interplay of catalysis and toxicity by amyloid intermediates on lipid bilayers: insights from type II diabetes

4 February 2020

cites work

1 reference

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Dynamic -Helix Structure of Micelle-bound Human Amylin

29 May 2018

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Amyloid formation by globular proteins under native conditions

29 May 2018

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Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy

29 May 2018

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Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.

29 May 2018

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Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding

29 May 2018

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Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.

29 May 2018

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Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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Mechanisms of protein fibril formation: nucleated polymerization with competing off-pathway aggregation

29 May 2018

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Fiber-dependent amyloid formation as catalysis of an existing reaction pathway

29 May 2018

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Membrane interaction of islet amyloid polypeptide

29 May 2018

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Direct detection of transient alpha-helical states in islet amyloid polypeptide

29 May 2018

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The effects of cosolutes on protein dynamics: the reversal of denaturant-induced protein fluctuations by trimethylamine N-oxide

29 May 2018

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Protein misfolding, functional amyloid, and human disease

29 May 2018

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Aspects on human amyloid forms and their fibril polypeptides

29 May 2018

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Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid

29 May 2018

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Measurement of intermediate exchange phenomena

29 May 2018

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Progress towards a molecular-level structural understanding of amyloid fibrils

29 May 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

29 May 2018

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Full-length rat amylin forms fibrils following substitution of single residues from human amylin

29 May 2018

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NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution

29 May 2018

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Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus

29 May 2018

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Amyloidogenicity and cytotoxicity of islet amyloid polypeptide

29 May 2018

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Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology

29 May 2018

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Nuclear magnetic resonance methods for elucidation of structure and dynamics in disordered states

29 May 2018

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29 May 2018

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The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease

29 May 2018

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Chemical shifts as a tool for structure determination

29 May 2018

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Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

29 May 2018

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Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants

29 May 2018

1 reference

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Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343364

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

29 May 2018

1 reference

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Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state

29 May 2018

1 reference

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Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

17 August 2018

1 reference

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Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

17 August 2018

1 reference

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Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative amyloidogenic domain: is there a critical amyloidogenic domain in human IAPP?

17 August 2018

1 reference

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Lipid membranes modulate the structure of islet amyloid polypeptide.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343364

Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling

17 August 2018

1 reference

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Phospholipid catalysis of diabetic amyloid assembly

17 August 2018

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Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation.

17 August 2018

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Lipid binding inhibits alpha-synuclein fibril formation

17 August 2018

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Islet amyloid: phase partitioning and secondary nucleation are central to the mechanism of fibrillogenesis.

17 August 2018

1 reference

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Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

17 August 2018

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Islet amyloid polypeptide: identification of long-range contacts and local order on the fibrillogenesis pathway

17 August 2018

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Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

17 August 2018

1 reference

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A helical capping motif in ShK toxin and its role in helix stabilization.

17 August 2018

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Dissociation of the effects of amylin on osteoblast proliferation and bone resorption.

17 August 2018

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Development of the multiple sequence approximation within the AGADIR model of alpha-helix formation: comparison with Zimm-Bragg and Lifson-Roig formalisms.

17 August 2018

1 reference

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Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure

17 August 2018

1 reference

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Investigations of the molecular mechanism of metal-induced Abeta (1-40) amyloidogenesis

3 November 2018

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3 November 2018

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Conserved and Cooperative Assembly of Membrane-Bound α-Helical States of Islet Amyloid Polypeptide†

1 December 2018

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Amide proton temperature coefficients as hydrogen bond indicators in proteins

1 December 2018

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12 December 2020

An effective method for the discrimination of motional anisotropy and chemical exchange

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12 December 2020

Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes

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12 December 2020

Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils

1 reference

12 December 2020

Dynamic NMR Line-Shape Analysis Demonstrates that the Villin Headpiece Subdomain Folds on the Microsecond Time Scale

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12 December 2020

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

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12 December 2020

Measurement of diffusion constants for nucleic acids by NMR

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12 December 2020

Measurement of peptide aggregation with pulsed-field gradient nuclear magnetic resonance spectroscopy

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12 December 2020

Temperature dependence of intramolecular dynamics of the basic leucine zipper of GCN4: implications for the entropy of association with DNA

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12 December 2020

Evaluation of two simplified 15N-NMR methods for determining micros-ms dynamics of proteins

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12 December 2020

10.1016/J.JMB.2009.07.077

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19647750 AND SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19647750 AND SRC:MED&resulttype=core&format=json

4 February 2020

PubMed publication ID

19647750

1 reference