signal transducer and activator of transcription 3 (Q4210010)

STAT transcription factor, DNA-binding, N-terminal

1 reference

transcription factor STAT

1 reference

STAT transcription factor, coiled coil

1 reference

SH2 domain superfamily

1 reference

STAT transcription factor, N-terminal domain superfamily

1 reference

STAT transcription factor, protein interaction, protein family

1 reference

SH2 domain, protein family

1 reference

STAT transcription factor, DNA-binding domain, protein family

1 reference

STAT3, SH2 domain, protein family

1 reference

STAT transcription factor, all-alpha domain, protein family

1 reference

DNA-binding transcription factor activity

1 reference

13 November 2019

1 reference

13 November 2019

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

16 July 2018

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40763&geneProductId=UniProtKB:P40763

nuclear receptor activity

1 reference

9 May 2019

Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

protein phosphatase binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

protein binding

51 references

9 May 2019

Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Acetylation Directs Survivin Nuclear Localization to Repress STAT3 Oncogenic Activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Identification of STAT3 as a specific substrate of breast tumor kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

MEN2A-RET-induced cellular transformation by activation of STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

PTP1B regulates leptin signal transduction in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Physical and functional interactions between Daxx and STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Crif1 is a novel transcriptional coactivator of STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phospho-tyrosine dependent protein-protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

A Complex of Nuclear Factor I-X3 and STAT3 Regulates Astrocyte and Glioma Migration through the Secreted Glycoprotein YKL-40

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

sequence-specific DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

16 July 2018

Interleukin-6 induces hepcidin expression through STAT3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40763&geneProductId=UniProtKB:P40763

chromatin DNA binding

1 reference

9 May 2019

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

identical protein binding

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

DNA-binding transcription factor activity, RNA polymerase II-specific

A census of human transcription factors: function, expression and evolution

4 references

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

NAS

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

Norwegian University of Science and Technology, Systems Biology team

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

signal transducer activity

1 reference

24 April 2018

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40763&geneProductId=UniProtKB:P40763

transcription factor binding

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

CCR5 chemokine receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

glucocorticoid receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Interleukin-6 induces hepcidin expression through STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

cell component

cytoplasm

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

mitochondrion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

mitochondrial inner membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

postsynaptic density

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

Schaffer collateral - CA1 synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

glutamatergic synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

transcription regulator complex

1 reference

9 May 2019

Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

13 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

cytosol

negative regulation of glycolytic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

protein import into nucleus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

response to organic substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of gene silencing by miRNA

1 reference

9 May 2019

STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

stem cell population maintenance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

cellular response to hormone stimulus

1 reference

9 May 2019

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

regulation of mitochondrial membrane permeability

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

growth hormone receptor signaling pathway

1 reference

9 May 2019

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

miRNA-mediated gene silencing by inhibition of translation

1 reference

9 May 2019

STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of metalloendopeptidase activity

1 reference

9 May 2019

STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

response to ethanol

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

negative regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

response to cytokine

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

3 references

9 May 2019

9 May 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

negative regulation of cell death

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40763&geneProductId=UniProtKB:P40763

1 reference

16 July 2018

positive regulation of growth factor dependent skeletal muscle satellite cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

4 references

9 May 2019

ISS

9 May 2019

STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

negative regulation of hydrogen peroxide biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

negative regulation of neuron death

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

leptin-mediated signaling pathway

cellular response to organic cyclic compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

negative regulation of apoptotic process

1 reference

9 May 2019

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

nervous system development

1 reference

9 May 2019

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of ATP biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

intracellular receptor signaling pathway

1 reference

9 May 2019

Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

acute-phase response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

negative regulation of neuron migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

receptor signaling pathway via JAK-STAT

2 references

8 April 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

response to organic cyclic compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

somatic stem cell population maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

regulation of multicellular organism growth

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

ageing

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

response to peptide hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

cellular response to leptin stimulus

1 reference

9 May 2019

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

signal transduction

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

positive regulation of transcription by RNA polymerase II

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Interleukin-6 induces hepcidin expression through STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

growth hormone receptor signaling pathway via JAK-STAT

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

8 April 2019

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of gene expression

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

negative regulation of stem cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

mRNA transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of erythrocyte differentiation

1 reference

9 May 2019

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of pri-miRNA transcription by RNA polymerase II

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of tyrosine phosphorylation of STAT protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

interleukin-15-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

interleukin-7-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

positive regulation of angiogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of vascular endothelial cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

interleukin-21-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

interleukin-23-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

interleukin-6-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

7 references

9 May 2019

9 May 2019

Interleukin-6 induces hepcidin expression through STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

interleukin-27-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

interleukin-35-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

interleukin-9-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

1 reference

9 May 2019

modulation of chemical synaptic transmission

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

postsynapse to nucleus signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

negative regulation of autophagy

1 reference

9 May 2019

IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of cell migration

1 reference

9 May 2019

β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

defense response

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

receptor signaling pathway via JAK-STAT

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

3 references

9 May 2019

9 May 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

NAS

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

leptin-mediated signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

regulation of cell population proliferation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

positive regulation of transcription by RNA polymerase II

Interleukin-6 induces hepcidin expression through STAT3

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

growth hormone receptor signaling pathway via JAK-STAT

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763

http://purl.uniprot.org/uniprot/P40763

Gene Atlas image

PBB GE STAT3 208991 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

1 reference

STAT transcription factor, all-alpha domain

1 reference

STAT transcription factor, DNA-binding

1 reference

STAT transcription factor, protein interaction

1 reference

STAT3, SH2 domain

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

D050796

subject named as

STAT3 Transcription Factor

0 references

MeSH tree code

D12.644.360.024.342.300

0 references

D12.776.157.057.186.300

0 references

D12.776.476.024.430.300

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

language of work or name

1 reference

UMLS 2023