Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. (Q42094327)

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25 December 2019

title

Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W (English)

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25 December 2019

2

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25 December 2019

author name string

Harshica Fernando

series ordinal

1

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25 December 2019

Christopher C Chin

series ordinal

3

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25 December 2019

James R Halpert

series ordinal

4

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25 December 2019

language of work or name

English

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publication date

12 January 2007

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25 December 2019

number of pages

12

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Archives of Biochemistry and Biophysics

inferred from page(s)

published in

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volume

460

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25 December 2019

issue

1

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25 December 2019

page(s)

129-140

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

25 December 2019

cites work

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Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration

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Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

29 May 2018

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Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.

29 May 2018

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Structure and chemistry of cytochrome P450.

29 May 2018

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Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe

29 May 2018

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Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

29 May 2018

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"Allosterism" in the elementary steps of the cytochrome P450 reaction cycle

29 May 2018

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Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

29 May 2018

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An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

29 May 2018

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Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes

29 May 2018

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Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity

29 May 2018

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A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation

29 May 2018

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

29 May 2018

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Cytochrome P-450 3A4: regulation and role in drug metabolism

29 May 2018

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Interactions among P450 enzymes when combined in reconstituted systems: formation of a 2B4-1A2 complex with a high affinity for NADPH-cytochrome P450 reductase.

29 May 2018

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Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

29 May 2018

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Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5

29 May 2018

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Rotation of cytochrome P-450. I. Investigations of protein-protein interactions of cytochrome P-450 in phospholipid vesicles and liver microsomes.

29 May 2018

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Determination of the partial specific volume of cytochrome P-450 as a model of a membrane protein.

29 May 2018

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Cytochrome P-450 spin state and leakiness of the monooxygenase pathway

29 May 2018

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Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations

29 May 2018

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Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

17 August 2018

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NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity

17 August 2018

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Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

17 August 2018

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The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria

17 August 2018

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Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment

17 August 2018

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The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

17 August 2018

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Effector-mediated alteration of substrate orientation in cytochrome P450 2C9.

17 August 2018

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An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

17 August 2018

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Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.

17 August 2018

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17 August 2018

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Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site

17 August 2018

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Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate

17 August 2018

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Evidence supporting the interaction of CYP2B4 and CYP1A2 in microsomal preparations

17 August 2018

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Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model

17 August 2018

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Binding and oxidation of alkyl 4-nitrophenyl ethers by rabbit cytochrome P450 1A2: evidence for two binding sites

17 August 2018

1 reference

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Stabilization of P450 2B4 by its association with P450 1A2 revealed by high-pressure spectroscopy.

17 August 2018

1 reference

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Complex formation in vesicle-reconstituted mitochondrial cytochrome P450 systems (CYP11A1 and CYP11B1) as evidenced by rotational diffusion experiments using EPR and ST-EPR.

17 August 2018

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Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

17 August 2018

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Thermodynamic studies of substrate binding and spin transitions in human cytochrome P-450 3A4 expressed in yeast microsomes.

17 August 2018

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Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site

17 August 2018

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Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.

17 August 2018

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High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers.

17 August 2018

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Kinetic studies on reduction of cytochromes P-450 and b5 by dithionite.

17 August 2018

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Determination of the sedimentation coefficient distribution by least-squares boundary modeling

17 August 2018

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12 December 2020

Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics

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Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone

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Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4

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Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models: Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

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Tyrosine motions in relation to the ferric spin equilibrium of cytochrome P-450cam

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Quaternary structure of the liver microsomal cytochrome P-450

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Interactions among cytochromes P-450 in the endoplasmic reticulum. Detection of chemically cross-linked complexes with monoclonal antibodies

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Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics

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Heteroactivator effects on the coupling and spin state equilibrium of CYP2C9

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Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4

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Hydrodynamic properties of monomeric cytochromes P-450LM2 and P-450LM4 in n-octylglucoside solution

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Determination of binding stoichiometry by the continuous variation method: the Job plot

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Conformation and rotational diffusion of cytochrome P-450 changed by substrate binding

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10.1016/J.ABB.2006.12.025

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17274942 AND SRC:MED&resulttype=core&format=json

25 December 2019

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25 December 2019

PubMed publication ID

17274942

1 reference