Simulation and Prediction of the Drug-Drug Interaction Potential of Naloxegol by Physiologically Based Pharmacokinetic Modeling (Q42071305)

16 October 2017

Simulation and Prediction of the Drug-Drug Interaction Potential of Naloxegol by Physiologically Based Pharmacokinetic Modeling (English)

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16 October 2017

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D Zhou

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16 October 2017

K Bui

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2

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16 October 2017

M Sostek

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3

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16 October 2017

N Al-Huniti

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4

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16 October 2017

language of work or name

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16 April 2016

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CPT: pharmacometrics & systems pharmacology

16 October 2017

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16 October 2017

5

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16 October 2017

5

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16 October 2017

250-257

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Absorption, distribution, metabolism, and excretion of [14C]-labeled naloxegol in healthy subjects

16 October 2017

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Clinical relevance of P-glycoprotein in drug therapy

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Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of naloxegol at peripheral and central nervous system receptors in healthy male subjects: A single ascending-dose study.

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1 reference

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Naloxegol for opioid-induced constipation in patients with noncancer pain

17 August 2018

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A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation

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Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies

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Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

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The effects of renal impairment on the pharmacokinetics, safety, and tolerability of naloxegol

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12 December 2020

Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents

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The effect of quinidine, a strong P-glycoprotein inhibitor, on the pharmacokinetics and central nervous system distribution of naloxegol

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P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans

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Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human

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Determination of the pKaand pH-Solubility Behavior of an Ionizable Cyclic Carbamate, (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one (DMP 266)

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12 December 2020

Identifiers

DOI

10.1002/PSP4.12070

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16 October 2017

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16 October 2017

PubMed publication ID

27299937

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