A role for the transcriptional repressor Blimp-1 in CD8( ) T cell exhaustion during chronic viral infection. (Q42055809)

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5 February 2020

title

A role for the transcriptional repressor Blimp-1 in CD8( ) T cell exhaustion during chronic viral infection (English)

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1

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Andrew Intlekofer

3

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7

E John Wherry

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author name string

Shawn D Blackburn

2

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Charlly Kao

4

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5 February 2020

Jill M Angelosanto

5

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Steven L Reiner

6

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language of work or name

English

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publication date

6 August 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19664943 AND SRC:MED&resulttype=core&format=json

5 February 2020

volume

31

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issue

2

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page(s)

309-320

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A vital role for interleukin-21 in the control of a chronic viral infection

5 February 2020

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IL-21 is required to control chronic viral infection

5 June 2018

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The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

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Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival

5 June 2018

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Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

5 June 2018

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Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

5 June 2018

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Molecular signature of CD8 T cell exhaustion during chronic viral infection

5 June 2018

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Heterogeneity and cell-fate decisions in effector and memory CD8 T cell differentiation during viral infection

5 June 2018

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Inflammation directs memory precursor and short-lived effector CD8( ) T cell fates via the graded expression of T-bet transcription factor

5 June 2018

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Requirement for T-bet in the aberrant differentiation of unhelped memory CD8 T cells.

5 June 2018

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Loss of T cell receptor-induced Bmi-1 in the KLRG1( ) senescent CD8( ) T lymphocyte

5 June 2018

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CD8 T cell dysfunction during chronic viral infection.

5 June 2018

1 reference

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Germ cell specification in mice

5 June 2018

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Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

5 June 2018

1 reference

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Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8 T cell functions during chronic viral infection.

5 June 2018

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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

5 June 2018

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Effector and memory CTL differentiation

5 June 2018

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Interleukin-10 determines viral clearance or persistence in vivo

5 June 2018

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Resolution of a chronic viral infection after interleukin-10 receptor blockade

5 June 2018

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Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade

5 June 2018

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Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland

5 June 2018

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Transcription factors that regulate memory in humoral responses

5 June 2018

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Restoring function in exhausted CD8 T cells during chronic viral infection

5 June 2018

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Effector and memory CD8 T cell fate coupled by T-bet and eomesodermin

5 June 2018

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Blimp1 is a critical determinant of the germ cell lineage in mice

5 June 2018

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BCL6b mediates the enhanced magnitude of the secondary response of memory CD8 T lymphocytes

5 June 2018

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Antigen-independent memory CD8 T cells do not develop during chronic viral infection

5 June 2018

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Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8 T cells

5 June 2018

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The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo

5 June 2018

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

5 June 2018

1 reference

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Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

5 June 2018

1 reference

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Binary and graded responses in gene networks

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747257

HIV-specific CD8( ) T cells produce antiviral cytokines but are impaired in cytolytic function

5 June 2018

1 reference

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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747257

The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747257

Modelling T-cell memory by genetic marking of memory T cells in vivo

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747257

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747257

Upregulation of CTLA-4 by HIV-specific CD4 T cells correlates with disease progression and defines a reversible immune dysfunction

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747257

Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

17 August 2018

1 reference

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Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production

17 August 2018

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Transcriptional regulator Id2 mediates CD8 T cell immunity.

17 August 2018

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Multilineage transcriptional priming and determination of alternate hematopoietic cell fates

17 August 2018

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Blimp-1 specifies neural crest and sensory neuron progenitors in the zebrafish embryo

17 August 2018

1 reference

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Granule-dependent mechanisms of lysis are defective in CD8 T cells of HIV-infected, antiretroviral therapy-treated individuals

17 August 2018

1 reference

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Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

17 August 2018

1 reference

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Cutting edge: rapid in vivo killing by memory CD8 T cells

17 August 2018

1 reference

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Ablation of CD8 and CD4 T cell responses by high viral loads

17 August 2018

1 reference

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Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2747257

HIV-specific CD8 T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

17 August 2018

1 reference

12 December 2020

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

1 reference

12 December 2020

Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

1 reference

12 December 2020

Transcription factors that behave as master regulators during mammalian embryogenesis function as molecular rheostats

1 reference

12 December 2020

10.1016/J.IMMUNI.2009.06.019

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19664943 AND SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19664943 AND SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

19664943

1 reference