Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest. (Q42003221)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556682 AND SRC:MED&resulttype=core&format=json

8 March 2020

title

Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest (English)

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8 March 2020

1 reference

4

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8 March 2020

Yehuda G Assaraf

6

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8 March 2020

author name string

S Raz

1

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8 March 2020

D Sheban

2

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8 March 2020

N Gonen

3

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8 March 2020

B Berman

5

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8 March 2020

publication date

20 February 2014

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8 March 2020

published in

Cell Death and Disease

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8 March 2020

volume

5

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8 March 2020

page(s)

e1067

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Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance

8 March 2020

cites work

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5 June 2018

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The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed

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5 June 2018

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5 June 2018

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Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

5 June 2018

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HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia

5 June 2018

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Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha

5 June 2018

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S-adenosylhomocysteine metabolism in different cell lines: effect of hypoxia and cell density

5 June 2018

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5 June 2018

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5 June 2018

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Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1.

5 June 2018

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5 June 2018

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Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

5 June 2018

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DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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The Human GARS-AIRS-GART Gene Encodes Two Proteins Which Are Differentially Expressed during Human Brain Development and Temporally Overexpressed in Cerebellum of Individuals with Down Dyndrome

5 June 2018

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5 June 2018

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Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene

5 June 2018

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Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

5 June 2018

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Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells

5 June 2018

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The biosynthetic pathway of pyrimidine (deoxy)nucleotides: a sensor of oxygen tension necessary for maintaining cell proliferation?

5 June 2018

1 reference

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Cancer chemotherapy: a critical analysis of its 60 years of history

5 June 2018

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Visualizing the effect of hypoxia on fluorescence kinetics in living HeLa cells using the fluorescent ubiquitination-based cell cycle indicator (Fucci).

17 August 2018

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Nucleoside transporter proteins

17 August 2018

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The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

17 August 2018

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CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer

17 August 2018

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Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter

17 August 2018

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Role of ribonucleotide reductase and deoxynucleotide pools in the oxygen-dependent control of DNA replication in Ehrlich ascites cells.

17 August 2018

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Heterogeneous oxygenation of rectal carcinomas in humans: a critical parameter for preoperative irradiation?

17 August 2018

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12 December 2020

Restimulation of cell cycle progression by hypoxic tumour cells with deoxynucleosides requires ppm oxygen tension

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Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

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Evidence that SP1 modulates transcriptional activity of the multidrug resistance-associated protein gene

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12 December 2020

Functional structure of the promoter region of the human thymidylate synthase gene and nuclear factors that regulate the expression of the gene

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HIF stabilizing agents: shotgun or scalpel?

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Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes

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Identifiers

DOI

10.1038/CDDIS.2014.39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556682 AND SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556682 AND SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

24556682

1 reference

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